2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Suppliers list

Company Name:	Jilin Province Woda Biotechnology Co., Ltd. Gold
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Company Name:	Daicel Chiral Technologies (China)CO.,LTD
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Company Name:	Shanghai Topbiochem Technology Co., Ltd
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2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione manufacturers

2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Basic information

Product Name:	2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
Synonyms:	2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5,6-difluoro-;6-difluoroisoindoline-1;6-Dioxopiperidin-3-yl)-5;Thalidomide-5,6-F;2-(2,6-Dioxo-3-piperidyl)-5,6-difluoroisoindoline-1,3-dione;5,6-Difluoro-thalidomide,AUN97411;Poma-5,6-2F
CAS:	1496997-41-1
MF:	C13H8F2N2O4
MW:	294.21
EINECS:
Product Categories:
Mol File:	1496997-41-1.mol

2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Chemical Properties

Boiling point	534.6±50.0 °C(Predicted)
density	1.633±0.06 g/cm3(Predicted)
storage temp.	2-8°C, sealed storage, away from moisture
form	Solid
pka	10.50±0.40(Predicted)
color	Off-white to gray
InChI	InChI=1S/C13H8F2N2O4/c14-7-3-5-6(4-8(7)15)13(21)17(12(5)20)9-1-2-10(18)16-11(9)19/h3-4,9H,1-2H2,(H,16,18,19)
InChIKey	AGHXYRKTAZEQQW-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C=C(F)C(F)=C2)C(=O)N1C1CCC(=O)NC1=O

Safety Information

MSDS Information

2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Usage And Synthesis

Description	Thalidomide-5,6-F is used in the recruitment of the cereblon protein and also used as a PROTAC linker.
Uses	Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].
IC 50	Cereblon
References	[1] Liu K, et al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013;11(29):4757-4763. DOI:10.1039/c3ob40595h

2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Preparation Products And Raw materials

Tag:2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione(1496997-41-1) Related Product Information

2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4,5-difluoro- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 2-[(3R)-2,6-dioxo-3-piperidinyl]-4-fluoro- 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-fluoro- 2-[(3S)-2,6-Dioxo-3-piperidinyl]-5-fluoro-1H-isoindole-1,3(2H)-dione