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| | 4-BROMO-2,6-DIMETHOXY-PYRIMIDINE Basic information |
| Product Name: | 4-BROMO-2,6-DIMETHOXY-PYRIMIDINE | | Synonyms: | 4-BROMO-2,6-DIMETHOXY-PYRIMIDINE;6-Bromo-2,4-dimethoxypyrimidine;Pyrimidine, 4-bromo-2,6-dimethoxy-;4-BROMO-2,6-DIMETHOXY-PYRIMIDINE ISO 9001：2015 REACH | | CAS: | 60186-89-2 | | MF: | C6H7BrN2O2 | | MW: | 219.04 | | EINECS: | | | Product Categories: | | | Mol File: | 60186-89-2.mol |  |
| | 4-BROMO-2,6-DIMETHOXY-PYRIMIDINE Chemical Properties |
| Boiling point | 294.7±43.0 °C(Predicted) | | density | 1.563±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -1.75±0.30(Predicted) | | Appearance | White to light yellow Solid |
| | 4-BROMO-2,6-DIMETHOXY-PYRIMIDINE Usage And Synthesis |
| Synthesis | To a 2L three-necked round-bottomed flask was added 2,4,6-tribromopyrimidine (54 g, 170.47 mmol, 1 eq.), methanol (500 mL), ethyl ether (500 mL), and a methanolic solution of sodium methanolate (30%, 76.7 g, 2.50 eq.), dropwise. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated in vacuum. The concentrate was diluted with 1 L of ethyl acetate and the organic layer was subsequently washed with 3 x 500 mL of saturated sodium chloride solution. The organic layer was again concentrated in vacuum. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:100 to 1:10) as eluent. The fractions containing the target product were combined and concentrated in vacuo to afford 23 g (62% yield) of 4-bromo-2,6-dimethoxypyrimidine as a white solid. The product was confirmed by LC-MS analysis: (ES, m/z): RT = 1.287 min, LCMS 28: m/z = 219 [M + 1]. | | References | [1] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 01122; 01125-01127 |
| | 4-BROMO-2,6-DIMETHOXY-PYRIMIDINE Preparation Products And Raw materials |
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