1-(4-Chlorophenyl)-2-methyl-2-propanol

104-83-6

5468-97-3

Example 1: Synthesis of 1-(4-chlorophenyl)-2-methyl-2-propanol 1. In a three-necked flask equipped with a stirrer and reflux condenser, a solution of 4-chlorobenzyl chloride (165 g, 1.02 mol) in ether (500 ml) was added. 2. Magnesium flakes (24.3 g, 1.00 mol) were added slowly and dropwise over a period of 1 h. The reaction mixture began to reflux spontaneously. 3. After continuing to reflux for 1 hr, the reaction solution was cooled to room temperature. 4. 4. add acetone (60.0 g, 1.30 mol) dropwise to the reaction mixture. 5. Heat the reaction mixture to reflux for 3 hours. 6. 6. Upon completion of the reaction, the reaction mixture was cooled and poured into a mixture of ice (500 ml) and concentrated hydrochloric acid (92 ml). 7. Separate the organic and aqueous phases. 8. The organic phase was washed with water and subsequently dried with anhydrous sodium sulfate. 9. The solvent was removed by vacuum evaporation to give the crude product. 10. The crude product was purified by fractional distillation and the fractions with a boiling point of 123°-124 °C/12 mmHg were collected to give 1-(4-chlorophenyl)-2-methyl-2-propanol (nD25 = 1.5300; 128.5 g, 70% yield).