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- IRAK-1/4 INHIBITOR I
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- $1.00
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2019-12-26
- CAS:509093-47-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 200kg
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| | IRAK-1/4 INHIBITOR I Basic information |
| Product Name: | IRAK-1/4 INHIBITOR I | | Synonyms: | 3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide;BenzaMide, N-[1-[2-(4-Morpholinyl)ethyl]-1H-benziMidazol-2-yl]-3-nitro-;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;IIRAK-1-4 Inhibitor I;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;IRAK-1/4 INHIBITOR I | | CAS: | 509093-47-4 | | MF: | C20H21N5O4 | | MW: | 395.41 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 509093-47-4.mol |  |
| | IRAK-1/4 INHIBITOR I Chemical Properties |
| density | 1.40 | | storage temp. | 2-8°C | | solubility | DMSO: ≥5mg/mL | | form | Yellow crystalline solid | | pka | 11.54±0.43(Predicted) | | color | off-white to light yellow | | InChI | InChI=1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26) | | InChIKey | QTCFYQHZJIIHBS-UHFFFAOYSA-N | | SMILES | C(NC1N(CCN2CCOCC2)C2=CC=CC=C2N=1)(=O)C1=CC=CC([N+]([O-])=O)=C1 |
| Hazard Codes | T | | Risk Statements | 25-36/37/38 | | Safety Statements | 26-36/37-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | IRAK-1/4 INHIBITOR I Usage And Synthesis |
| Uses | IRAK-1/4 Inhibitor (interleukin-1 receptor-associated kinases) are important mediators in signal transduction of TIR family members. This regulation protects against the development of cancers and other diseases. | | Uses | IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines. | | Biological Activity | irak-1-4 inhibitor i is an inhibitor of both irak-1 and irak-4 with ic50 values of 0.3μm and 0.2μm , respectively [1].il-1 receptor-associated kinases play important roles in signal transduction. there are totally four members of the iraks, they are irak-1, irak-2, irak-m and irak-4. irak-4 can activate nf-κb and mapk pathways and it is shown that the inhibition of irak-4 can be an anti-inflammatory therapy. irak-1-4 inhibitor i is an analog of an initial irak-4 inhibitor hit, which is screened out from a small molecule li brary against irak-4. with the less basic n-ethylenemorpholine moiety, irak-1-4 inhibitor i has a higher potency than other analogs. additionally, it does not show any cytotoxicity in a 72 h proliferation assay in hela cells(ed50 >30μm) [1]. | | Biochem/physiol Actions | IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibitinhibitory effects on the nuclear factor (NF)-κB signaling pathway. | | storage | Store at -20°C | | references | [1] jay p. powers, shyun li, juan c. jaen, jinqian liu, nigel p. c. walker, zhulun wang and holger wesche. discovery and initial sar of inhibitors of interleukin-1 receptor-associated kinase-4. bioorganic & medicinal chemistry letters. 2006, 16: 2842–2845. |
| | IRAK-1/4 INHIBITOR I Preparation Products And Raw materials |
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