| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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- Fluorouracil-001
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- $1.00
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2020-05-15
- CAS: 3013-92-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20T
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| | 5-Fluoro-1,3-dimethyluracil Basic information |
| Product Name: | 5-Fluoro-1,3-dimethyluracil | | Synonyms: | 1,3-Dimethyl-5-fluorouracil, 2,4-Dihydroxy-1,3-dimethyl-5-fluoropyrimidine;1,3-dimethyl-5-fluorouracil;2,4(1H,3H)-Pyrimidinedione,5-fluoro-1,3-dimethyl-;Fluorouracil-001;5-Fluoro-1,3-dimethyluracil 99%;5-fluoro-1,3-dimethylpyrimidine-2,4-dione;Fluorouracil Impurity 34;5-fluoro-1,3-diMethylpyriMidine-2,4(1H,3H)-dione | | CAS: | 3013-92-1 | | MF: | C6H7FN2O2 | | MW: | 158.13 | | EINECS: | | | Product Categories: | | | Mol File: | 3013-92-1.mol |  |
| | 5-Fluoro-1,3-dimethyluracil Chemical Properties |
| Melting point | 132-134 °C(lit.) | | Boiling point | 182.5±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | pka | -4.07±0.40(Predicted) | | BRN | 880396 | | InChI | 1S/C6H7FN2O2/c1-8-3-4(7)5(10)9(2)6(8)11/h3H,1-2H3 | | InChIKey | DDEWVRFHURYTHA-UHFFFAOYSA-N | | SMILES | CN1C=C(F)C(=O)N(C)C1=O |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 5-Fluoro-1,3-dimethyluracil Usage And Synthesis |
| Uses | 5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:
- Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.
- To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.
- To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.
| | Synthesis Reference(s) | Tetrahedron, 46, p. 3093, 1990 DOI: 10.1016/S0040-4020(01)88400-3 | | General Description | Oxidation of 5-fluoro-1,3-dimethyluracil (5-FDMU) with m-chloroperbenzoic acid has been described. It is reported as antineoplastic drug. On photoirradiation, 5-fluoro-1,3-dimethyluracil yields the trans-anti cyclobutane dimer and the cis-syn cyclobutane dimer. UV irradiation of 5-FDMU and naphthalene in a protic medium affords 5-(1-naphthyl)uracil, while in aprotic media it undergoes stereoselective 1,4-cycloaddition reaction to give a barrelene derivative. The thermochemical parameters of 5-FDMU has been determined. It reacts with substituted benzenes in the presence of trifluoroacetic acid to generate 5-aryl-1,3-dimethyluracils via photosubstitution. |
| | 5-Fluoro-1,3-dimethyluracil Preparation Products And Raw materials |
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