| Company Name: |
SPIRO PHARMA |
| Tel: |
|
| Email: |
eric_feng1954@126.com |
CB 3717 manufacturers
- CB 3717
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- $3480.00
-
2026-05-21
- CAS:76849-19-9
- Purity:
- Supply Ability: 10g
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| | CB 3717 Basic information |
| Product Name: | CB 3717 | | Synonyms: | CB 3717;10-Propargyl-5,8-dideazafolate;N-[4-[[(2-Amino-1,4-dihydro-4-oxoquinazolin-6-yl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid;N-[p-[Propargyl(2-amino-4-hydroxyquinazolin-6-ylmethyl)amino]benzoyl]-L-glutamic acid;LTKHPMDRMUCUEB-IBGZPJMESA-N;L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]benzoyl]-;8-dideazafolic acid;N(sup 10)-Propargyl-5 | | CAS: | 76849-19-9 | | MF: | C24H23N5O6 | | MW: | 477.47 | | EINECS: | | | Product Categories: | | | Mol File: | 76849-19-9.mol |  |
| | CB 3717 Chemical Properties |
| | CB 3717 Usage And Synthesis |
| Description | CB 3717, a potent inhibitor of
thymidylate synthase, is toxic for cell lines with
altered dihydrofolate reductase; and homofolate, a de novo purine inhibitor requiring dihydrofolate reductase for activation, is effective
in reductase-amplified lines. | | Uses | CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells[1]. | | Definition | ChEBI: CB3717 is a N-acyl-L-glutamic acid. | | Hazard | A poison. | | References | [1] Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells DOI:10.1016/0006-2952(83)90150-8 |
| | CB 3717 Preparation Products And Raw materials |
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