[(3R)-3-Amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]methanone manufacturers
- JBI-589
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2026-07-29
- CAS:2308504-22-3
- Purity: 99.88%
- Supply Ability: 10g
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| | [(3R)-3-Amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]methanone Basic information |
| | [(3R)-3-Amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]methanone Chemical Properties |
| density | 1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | solubility | Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Slightly Soluble: 0.1-1 mg/ml | | form | Solid | | pka | 9.54±0.20(Predicted) | | color | Light yellow to yellow |
| | [(3R)-3-Amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]methanone Usage And Synthesis |
| Uses | JBI-589 is a non-covalent PAD4 isoform-selective inhibitor with oral bioavailability. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors. JBI-589 can be used in cancer research[1][2]. | | in vivo | JBI-589 (50 mg/kg, p.o., twice a day for 24 days) significantly inhibits the growth of primary tumors in LL2 and B16F10 tumor C57BL/6 mouse models[1]. | Animal Model: | LL2 tumor C57BL/6 mouse model; B16F10 tumor C57BL/6 mouse model | | Dosage: | 50 mg/kg | | Administration: | Oral gavage (p.o.), twice daily | | Result: | Led to a significant downregulation of CXCR2 receptor expression in Ly6G cells of the mice, while CXCR4 receptor expression remained unchanged.
Had no effect on the cell counts of bone marrow cells, CD8 T cells, and NK cells in tumor-bearing mice model. |
| | References | [1] Deng H, et al. A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression. Cancer Res. 2022 Oct 4;82(19):3561-3572. DOI:10.1158/0008-5472.CAN-21-4045
[2] Gajendran C, et al. Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4. Sci Rep. 2023 Feb 23;13(1):3189. DOI:10.1038/s41598-023-30246-2 |
| | [(3R)-3-Amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]methanone Preparation Products And Raw materials |
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