corydalmine manufacturers
- Corydalmine
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- $1478.00 / 1mg
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2026-04-21
- CAS:30413-84-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | corydalmine Basic information |
| Product Name: | corydalmine | | Synonyms: | corydalmine;(-)-Kikemanine;(13aS)-5,8,13,13a-Tetrahydro-2,3,9-trimethoxy-6H-dibenzo[a,g]quinolizin-10-ol;Kikemanin;Kikemanine;Schefferine;6H-Dibenzo[a,g]quinolizin-10-ol,5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (13aS)-;(13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol | | CAS: | 30413-84-4 | | MF: | C20H23NO4 | | MW: | 341.4 | | EINECS: | | | Product Categories: | | | Mol File: | 30413-84-4.mol |  |
| | corydalmine Chemical Properties |
| Melting point | 177-178℃ | | Boiling point | 501.2±50.0 °C(Predicted) | | density | 1.29 | | storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 9.97±0.20(Predicted) | | form | Powder | | InChI | InChI=1S/C20H23NO4/c1-23-18-9-13-6-7-21-11-15-12(4-5-17(22)20(15)25-3)8-16(21)14(13)10-19(18)24-2/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1 | | InChIKey | DIHXHTWYVOYYDC-INIZCTEOSA-N | | SMILES | C12=CC(OC)=C(OC)C=C1CCN1[C@@]2([H])CC2=CC=C(O)C(OC)=C2C1 |
| | corydalmine Usage And Synthesis |
| Uses | Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3]. | | in vivo | Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes[2]. | | target | P450 (e.g. CYP17) | Antifection | | IC 50 | CXCR2 | | References | [1] S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. DOI:10.4489/MYCO.2007.35.2.069
[2] Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. DOI:10.1016/j.jpba.2016.05.024
[3] Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47. DOI:10.1016/j.neuropharm.2018.03.004 |
| | corydalmine Preparation Products And Raw materials |
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