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| | Diethyl 2,6-pyridinedicarboxylate Basic information |
| Product Name: | Diethyl 2,6-pyridinedicarboxylate | | Synonyms: | Pyridinedicarboxylicaciddiethylester;2,6-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 98+%;2,6-Pyridinedicarboxylic acid diethyl ester ,99%;Nsc78907;Diethyl pyridine-1,6-dicarboxylate;2,6-diethyl pyridine-2,6-dicarboxylate;Diethyl Dipicolinate
2,6-Pyridinedicarboxylic Acid Diethyl Ester
Dipicolinic Acid Diethyl Ester;2,6-Pyridinedicarboxylic acid, 2,6-diethyl ester | | CAS: | 15658-60-3 | | MF: | C11H13NO4 | | MW: | 223.23 | | EINECS: | | | Product Categories: | Heterocycle-Pyridine series;Esters;Pyridines;API intermediates;Pyridines, Pyrimidines, Purines and Pteredines | | Mol File: | 15658-60-3.mol |  |
| | Diethyl 2,6-pyridinedicarboxylate Chemical Properties |
| Melting point | 44°C | | Boiling point | 188 °C / 12mmHg | | density | 1.165±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | -0.20±0.10(Predicted) | | color | White to Light yellow to Light orange | | CAS DataBase Reference | 15658-60-3(CAS DataBase Reference) |
| | Diethyl 2,6-pyridinedicarboxylate Usage And Synthesis |
| Chemical Properties | Yellow to red crystalline powder | | Synthesis | Pyridine-2,6-dicarboxylic acid (10.0g, 59.9mmol) was added into ethanol (120mL),
then 3 drops of concentrated sulfuric acid were added. The mixture was heated to
reflux for 8 hours. After evaporation of the solvent, the solid residue was washed with
saturated Na2CO3 aqueous solution and extracted with chloroform for 3 times. The
organic phase was dried with small amount of MgSO4. The solvent was removed to
afford 1 as white powder (12.6g, 56.3mmol, yield = 94%). 1
H-NMR (400MHz,
CDCl3) | ppm 8.29 (d, J = 7.80 Hz, 2H), 8.01 (t, J = 7.80, 7.80 Hz, 1H), 4.50 (q, J =
7.12, 7.12, 7.12 Hz, 2H), 1.47 (t, J = 7.13, 7.13 Hz, 3H). 13C-NMR (100 MHz, CDCl3)
| ppm 164.6, 148.6, 138.2,127.8, 62.3,14.2,14.2. ESI MS: m/z = 224.1 [M+H]+
, 246.1
[M+Na]+
.
 | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 9, p. 2599 - 2603
[2] Chemical Communications, 2008, # 21, p. 2444 - 2446
[3] Tetrahedron Letters, 2017, vol. 58, # 10, p. 991 - 994
[4] Molecular Crystals and Liquid Crystals, 2007, vol. 470, # 1, p. 369 - 381
[5] Organometallics, 2015, vol. 34, # 7, p. 1170 - 1176 |
| | Diethyl 2,6-pyridinedicarboxylate Preparation Products And Raw materials |
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