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| | Ac-Arg-Leu-Arg-AMC Basic information |
| Product Name: | Ac-Arg-Leu-Arg-AMC | | Synonyms: | Ac-Arg-Leu-Arg-AMC;Ac-Arg-Leu-Arg-AMC trifluoroacetate salt;N2-Acetyl-L-arginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide;L-Argininamide,N2-acetyl-L-arginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;Ac-RLR-AMC | | CAS: | 929903-87-7 | | MF: | C30H46N10O6 | | MW: | 642.75 | | EINECS: | | | Product Categories: | | | Mol File: | 929903-87-7.mol |  |
| | Ac-Arg-Leu-Arg-AMC Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | pka | 13.29±0.46(Predicted) | | color | Solid lyophilized powder | | Sequence | Ac-Arg-Leu-Arg-AMC |
| | Ac-Arg-Leu-Arg-AMC Usage And Synthesis |
| Uses | Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes[1]. | | Biological Activity | Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. It is cleaved exclusively at the amide R-AMC bond to release fluorescent product. Shows low Km and high specific activity. Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis. | | storage | +4°C | | References | [1] Chang TL. Inhibitory effect of flavonoids on 26S proteasome activity. J Agric Food Chem. 2009 Oct 28;57(20):9706-15. DOI:10.1021/jf9017492 |
| | Ac-Arg-Leu-Arg-AMC Preparation Products And Raw materials |
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