| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- Indo-1 AM
-
- $398.00
-
2026-07-15
- CAS:112926-02-0
- Purity:
- Supply Ability: 10g
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| | Indo 1-am Basic information |
| Product Name: | Indo 1-am | | Synonyms: | indo-1pentaacetoxymethylester;1-[2-AMINO-5-(6-CARBOXYINDOL-2-YL)PHENOXY]-2-(2'-AMINO-5'-METHYLPHENOXY) ETHANE-N,N,N',N'-TETRAACETIC ACID PENTAACETOXYMETHYL ESTER;1-[2-AMINO-5-(6-CARBOXYINDOL-2-YL)PHENOXY]-2-(2'-AMINO-5'-METHYLPHENOXY) ETHANE-N,N,N,N-TETRAACETIC ACID PENTAACETOXY-METHYL ESTER;4-(6-CARBOXY-2-INDOLYL)-4'-METHYL-2,2'-(ETHYLENEDIOXY)DIANILINE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL) ESTER;ACETOXYMETHYL ESTER OF INDO 1;INDO 1/AM (1SET = 10x100UG);INDO 1-AM >93% FLUORESCENT MARKER FO;INDO 1-AM, FOR FLUORESCENCE | | CAS: | 112926-02-0 | | MF: | C47H51N3O22 | | MW: | 1009.91 | | EINECS: | | | Product Categories: | Indole | | Mol File: | 112926-02-0.mol |  |
| | Indo 1-am Chemical Properties |
| Melting point | >250 ℃ | | Boiling point | 1009.2±65.0 °C(Predicted) | | density | 1.374±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble | | form | powder | | pka | 14.85±0.30(Predicted) | | color | Light yellow | | Appearance | Solid Powder | | λmax | 356nm | | Biological Applications | Calcium indicator; preventing arrhythmias | | InChIKey | CAWBRCOBJNWRLK-UHFFFAOYSA-N | | SMILES | CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc2cc(ccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c3cc4ccc(cc4[nH]3)C(=O)OCOC(C)=O |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 8-10 | | Storage Class | 11 - Combustible Solids |
| | Indo 1-am Usage And Synthesis |
| Description | Indo-1 AM is a cell-permeant acetoxymethyl ester of indo-1, a ratiometric fluorescent calcium indicator. Indo-1 AM is hydrolyzed by intracellular esterases to release Indo-1 in cells. Indo-1 is commonly used in flow cytometry. The emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium. | | Chemical Properties | yellow solid | | Uses | INDO 1/AM is a cell permeable derivative of INDO 1. | | Uses | Cell-permeant derivative of Indo 1. Indo 1-AM is fluorescent probe for Ca2+. After crossing the membrane, the product is rapidly hydrolyzed by cytoplasmic esterases to the membrane impermeant INDO 1. Indo 1-AM is possible using for ratiometric fluorescenc | | Uses | Cell permeable fluorescent probe for Ca2+; lower affinity than FURA2; gives a large shift in fluorescent emission from 482nm to 398nm upon Ca2+ binding. | | storage | -20°C | | Excitation / Emission Maximum | 349-364 nm/475-485 nm (no Ca2+), 400-410 nm (Ca2+-bound) |
| | Indo 1-am Preparation Products And Raw materials |
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