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| | 3-Dehydrotrametenolic acid Basic information |
| Product Name: | 3-Dehydrotrametenolic acid | | Synonyms: | 3β-Hydroxy-5α-lanosta-7,9(11),24-trien-21-oic acid;3beta-Hydroxylanosta-7,9(11),24-trien-21-oic acid;11,24-trien-21-oic acid;3beta-Hydroxylanosta-7,9;3-dehydrotrametenolic acid;Dehydrotrametenolic acid 3β-hydroxylanosta-7, 9(11),24-trien-21-oic acid;Lanosta-7,9(11),24-trien-21-oic acid, 3-hydroxy-, (3β)-;Dehydrotrametenolic acid
3β-hydroxylanosta-7,
9(11),24-trien-21-oic
acid | | CAS: | 29220-16-4 | | MF: | C30H46O3 | | MW: | 454.69 | | EINECS: | | | Product Categories: | | | Mol File: | 29220-16-4.mol |  |
| | 3-Dehydrotrametenolic acid Chemical Properties |
| Melting point | 257-259℃ | | Boiling point | 585.4±50.0 °C(Predicted) | | density | 1.08±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 4.63±0.10(Predicted) | | color | White to off-white | | InChIKey | QFPLAAZRZNKRRY-XUJPXTKYNA-N | | SMILES | [C@@H]1(O)C(C2[C@](C)(CC1)C1C([C@]3([C@@](CC=1)(C)[C@@H]([C@H](C(O)=O)CC/C=C(\C)/C)CC3)C)=CC2)(C)C |&1:0,4,10,11,15,16,r| |
| | 3-Dehydrotrametenolic acid Usage And Synthesis |
| Description | Dehydrotrametenolic acid (DTA) is a lanostane-type triterpene acid isolated from Poria cocos Wolf (Polyporaceae)，and has an anti-inflammatory and antidiabetic effects. The regulatory effects of DTA on skin hydration and keratinocyte differentiation are mediated by the MAPK/AP-1 and IκBα/NF-κB pathways. In addition, Dehydrotrametenolic acid could be a promising ingredient in cosmetics for moisturizing and increased skin barrier function.[1] | | Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Poria cocos. | | Uses | 3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity[1][2]. | | Biological Activity | 3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity. | | References | [1] EUNJU CHOI. In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function.[J]. ACS Applied Energy Materials, 2019. DOI:10.3390/molecules24244583.
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| | 3-Dehydrotrametenolic acid Preparation Products And Raw materials |
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