2-Chloro-4-ethoxy-6-methyl-pyrimidine manufacturers
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| | 2-Chloro-4-ethoxy-6-methyl-pyrimidine Basic information |
| Product Name: | 2-Chloro-4-ethoxy-6-methyl-pyrimidine | | Synonyms: | 2-Chloro-4-ethoxy-6-methyl-pyrimidine;2-Chloro-4-ethoxy-6-methyl-pyrimidine ISO 9001：2015 REACH;Pyrimidine, 2-chloro-4-ethoxy-6-methyl-;2-chloro-4-ethoxy-6-methyl-pyrimidine - [C86616] | | CAS: | 37482-64-7 | | MF: | C7H9ClN2O | | MW: | 172.61 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 37482-64-7.mol |  |
| | 2-Chloro-4-ethoxy-6-methyl-pyrimidine Chemical Properties |
| Melting point | 70-73℃ | | Boiling point | 282℃ | | density | 1.193 | | Fp | 124℃ | | storage temp. | Storage temp. 2-8°C | | pka | 0.76±0.30(Predicted) | | Appearance | White to off-white Solid |
| HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 2-Chloro-4-ethoxy-6-methyl-pyrimidine Usage And Synthesis |
| Uses | 2-Chloro-4-ethoxy-6-methylpyrimidine is a reactant/starting material in the preparation of azolylpyrimidines as cytoprotective antiulcer agents. | | Synthesis | General procedure: 2,4-dichloro-6-methylpyrimidine (3.0 g, 18.4 mmol), cesium carbonate (Cs2CO3, 6.6 g, 20.2 mmol) and ethanol (EtOH, 46 mL) were added to a reaction flask, and the mixture was stirred under reflux conditions for 48 hours. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was purified by column chromatography to afford the target product 2-chloro-4-ethoxy-6-methylpyrimidine (1.88 g, 59% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ6.47 (1H, s), 4.41 (2H, q), 2.42 (3H, s), 1.39 (3H, t). | | References | [1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0476
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5206 - 5220
[3] Patent: WO2016/133959, 2016, A1. Location in patent: Page/Page column 46; 47 |
| | 2-Chloro-4-ethoxy-6-methyl-pyrimidine Preparation Products And Raw materials |
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