4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE manufacturers
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| | 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE Basic information |
| Product Name: | 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE | | Synonyms: | 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE;4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine ,97%;4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine;4-Chloro-2-(methylsulfonyl)-6-methoxypyrimidine;4-Chloro-6-methoxy-2-(methylsulfonyl);Pyrimidine, 4-chloro-6-methoxy-2-(methylsulfonyl)-;4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE ISO 9001：2015 REACH | | CAS: | 89466-55-7 | | MF: | C6H7ClN2O3S | | MW: | 222.65 | | EINECS: | | | Product Categories: | | | Mol File: | 89466-55-7.mol |  |
| | 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE Chemical Properties |
| Melting point | 90-91℃ | | Boiling point | 405.1±48.0 °C(Predicted) | | density | 1.449 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -6.47±0.30(Predicted) | | Appearance | White to off-white Solid |
| Safety Statements | 24/25 | | HS Code | 29339900 |
| | 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | General method: 6-methoxy-2-methylthio-4-chloropyrimidine (5 mmol), tetrabutylammonium bromide (0.16 g, 0.5 mmol, 10 mol%) were mixed with acetone (20 mL) at room temperature and stirred. An aqueous solution of Oxone (12.5 mmol, 2.5 eq.) was slowly added (20 mL) with vigorous stirring. After 4-6 hours of reaction, complete consumption of the feedstock was confirmed by TLC monitoring. The reaction mixture was filtered through a Brewer's funnel and the resulting solid product was washed with water and dried to give 4-chloro-6-methoxy-2-methylsulfonylpyrimidine. The yield, melting point and spectral data of the product are shown below. | | References | [1] Synthetic Communications, 2018, vol. 48, # 6, p. 714 - 720
[2] Patent: US5599770, 1997, A
[3] Patent: US5723412, 1998, A |
| | 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE Preparation Products And Raw materials |
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