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Alfa Aesar |
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Energy Chemical |
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| | 4-Chloro-3-nitroaniline Basic information |
| | 4-Chloro-3-nitroaniline Chemical Properties |
| Melting point | 99-101 °C (lit.) | | Boiling point | 200°C (rough estimate) | | density | 1.5610 (rough estimate) | | refractive index | 1.5870 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 1.87±0.10(Predicted) | | color | White to Yellow to Orange | | BRN | 1309394 | | Henry's Law Constant | 1.8×103 mol/(m3Pa) at 25℃, HSDB (2015) | | InChI | InChI=1S/C6H5ClN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2 | | InChIKey | FOHHWGVAOVDVLP-UHFFFAOYSA-N | | SMILES | C1(N)=CC=C(Cl)C([N+]([O-])=O)=C1 | | CAS DataBase Reference | 635-22-3(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenamine, 4-chloro-3-nitro-(635-22-3) | | EPA Substance Registry System | 4-Chloro-3-nitroaniline (635-22-3) |
| Hazard Codes | T+,N,T | | Risk Statements | 26/27/28-33-51/53 | | Safety Statements | 28-36/37-45-61-28A | | RIDADR | UN 2237 6.1/PG 3 | | WGK Germany | 3 | | RTECS | BX1750000 | | Hazard Note | Very Toxic | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214210 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Dermal
Acute Tox. 2 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 2
STOT RE 2 | | Hazardous Substances Data | 635-22-3(Hazardous Substances Data) |
| | 4-Chloro-3-nitroaniline Usage And Synthesis |
| Chemical Properties | ochre powder | | Uses | Intermediate in the manufacture of azo dyes,
pharmaceuticals, and other organic compounds. | | Application | Commercial 4-chloro-3-nitroaniline could be used as a starting material for 3-azido-4-chlorophenylisothiocyanate through a 5-step synthesis. In order to research the impact of the strain on the metabolite profile of plasma samples in rats, 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) was evaluated for 4 weeks. 4C3N administration led to extravascular hemolytic anemia with a few metabolome changes, which were strain-dependent [1-2].
| | Hazard | Toxic by ingestion and inhalation. | | Safety Profile | Poison by ingestion and
intraperitoneal routes. Experimental
reproductive effects. Skin and eye irritant.
When heated to decomposition it emits
toxic fumes of NOx and Cl-. | | References |
[1] H. Lamotte. “Synthesis of N‐(3‐azido‐4‐chlorophenyl)‐N′‐[3H‐methyl] thiourea, an efficient photoaffinity probe for the urea carrier.” Journal of Labelled Compounds and Radiopharmaceuticals 42 1 (1994): 289–295.
[2] O’Donoghue, John L. “Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.” Fundamental and Applied Toxicology 6 3 (1986): Pages 551-558.
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| | 4-Chloro-3-nitroaniline Preparation Products And Raw materials |
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