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| | 4-Methyl-3-nitroaniline Basic information |
| | 4-Methyl-3-nitroaniline Chemical Properties |
| Hazard Codes | T,N,Xi | | Risk Statements | 23/24/25-33-51/53 | | Safety Statements | 28-36/37-45-61-28A | | RIDADR | UN 2660 6.1/PG 3 | | WGK Germany | 2 | | RTECS | XU8227250 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214300 | | Toxicity | LD50 orl-rat: 6860 mg/kg 28ZPAK -,133,72 |
| | 4-Methyl-3-nitroaniline Usage And Synthesis |
| Description | 4-Methyl-3-nitroaniline is one of the intermediates or products in the photochemical transformations (λ=254 nm) of 2,4-dinitrotoluene (2,4-DNT) in aqueous solutions containing the cationic surfactant cetyltrimethylammonium (CTA) and the anionic nucleophile borohydride (BH4-)[1]. | | Chemical Properties | Orange Crystalline Solid | | Uses | 4-Methyl-3-nitroaniline is a compound useful in organic synthesis. It is used to make pigments and dyes. It could also be used in Environmental Testing. It could be used as raw material to synthesized N-(4-methyl-3-nitrophenyl)-4-(4-methylpiperazin-1-ylmethyl)benzamide through acylation[2]. | | Definition | ChEBI: 4-Amino-2-nitrotoluene is a C-nitro compound. | | Synthesis Reference(s) | Tetrahedron Letters, 30, p. 251, 1989 DOI: 10.1016/S0040-4039(00)95173-6 | | Reactivity Profile | 4-Methyl-3-nitroaniline is incompatible with acids, acid chlorides, acid
anhydrides, chloroformates and strong oxidizing agents (NTP, 1992). | | Hazard | Toxic by ingestion. | | Fire Hazard | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive
(Combustible)]: Combustible material: may burn but does not ignite
readily. When heated, vapors may form explosive mixtures with air:
indoors, outdoors and sewers explosion hazards. Those substances
designated with a (P) may polymerize explosively when heated or involved
in a fire. Contact with metals may evolve flammable hydrogen
gas. Containers may explode when heated. Runoff may pollute waterways.
Substance may be transported in a molten form. (ERG, 2020) | | Safety Profile | Poison by ingestion andintravenous routes. Combustible when exposed to heat orflame. To fight fire, use CO2, spray, foam. When heated todecomposition it emits toxic fumes of NOx. | | Purification Methods | Crystallise the aniline from hot water (charcoal), then ethanol and dry it in a vacuum desiccator. [Beilstein 12 H 966.] | | References | [1] Diehl C, et al. Surfactant-assisted UV-photolysis of nitroarenes. Chemosphere, 2002; 46: 553-560.
[2] Koroleva E, et al. Synthesis of new amides of the N -methylpiperazine series. Russian Journal of Organic Chemistry, 2011; 47: 1556–1563. |
| | 4-Methyl-3-nitroaniline Preparation Products And Raw materials |
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