N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE manufacturers
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| | N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE Basic information |
| Product Name: | N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE | | Synonyms: | N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE;5-Acetamido-1-indanone;5-Acetylamino-1-indanone;5-Acetamido-2,3-dihydro-1-oxo-1H-indene;N-(1-Oxo-2,3-dihydro-1H-inden-5-yl);N-(2,3-dihydro-1-oxo-1H-inden-5-yl)acetamide;N-(1-Oxo-indan-5-yl)-acetamide;N-(2,3-Dihydro-1-oxo-1H-inden-5-yl)acetamide, 5-(Acetylamino)-2,3-dihydro-1-oxo-1H-indene, 5-Acetamido-2,3-dihydro-1-oxo-1H-indene | | CAS: | 58161-35-6 | | MF: | C11H11NO2 | | MW: | 189.21 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 58161-35-6.mol |  |
| | N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE Chemical Properties |
| Melting point | 172 °C | | Boiling point | 427.4±34.0 °C(Predicted) | | density | 1.277±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.53±0.20(Predicted) | | form | powder | | color | Yellow | | InChI | InChI=1S/C11H11NO2/c1-7(13)12-9-3-4-10-8(6-9)2-5-11(10)14/h3-4,6H,2,5H2,1H3,(H,12,13) | | InChIKey | GHUPGGYDRVSZSW-UHFFFAOYSA-N | | SMILES | C(NC1C=CC2=C(C=1)CCC2=O)(=O)C |
| Hazard Note | Harmful | | HS Code | 2924297099 |
| | N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE Usage And Synthesis |
| Definition | ChEBI: N1-(1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide is a member of indanones. | | Synthesis | General procedure for the synthesis of 5-acetamido-1-indanone from N-(2,3-dihydro-1H-inden-5-yl)acetamide: To a stirred solution of N-(2,3-dihydro-1H-inden-5-yl)acetamide (11.5 g, 65.7 mmol) in acetic acid: ethyl acetate (1:1, 200 ml) was slowly added dropwise to a solution of chromium trioxide (15 g) dissolved in water at 0 °C 151.11 mmol) dissolved in water. The reaction mixture was continued to be stirred at room temperature for 3 hours. After completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with methanol/dichloromethane as eluent to afford the target product 5-acetamido-1-indanone (9 g, 85% yield) as a yellow solid. m/z = 190 [M + H]+ by LC-MS. | | References | [1] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 548
[2] Journal of Chemical Research, 2013, vol. 37, # 4, p. 232 - 235
[3] Journal of Organic Chemistry, 1962, vol. 27, p. 70 - 76
[4] Physical Chemistry Chemical Physics, 2001, vol. 3, # 17, p. 3555 - 3561
[5] Patent: WO2013/62892, 2013, A1. Location in patent: Page/Page column 45 |
| | N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE Preparation Products And Raw materials |
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