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HG-14-10-04

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HG-14-10-04 manufacturers

  • HG-14-10-04
  • HG-14-10-04 pictures
  • $44.00
  • 2026-07-27
  • CAS:1356962-34-9
  • Purity: 99.76%
  • Supply Ability: 10g
HG-14-10-04 Basic information
Product Name:HG-14-10-04
Synonyms:HG-14-10-04;CS-2526;CS-1175;2-Pyrimidinamine, 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-;Anaplastic lymphoma kinase (ALK),HG 14 10 04,Anaplastic lymphoma kinase,ErbB-1,Inhibitor,EGFR,anticancer,HG141004,CD246,inhibit,HER1,Cluster of differentiation 246,Epidermal growth factor receptor,ALK tyrosine kinase receptor;HG-14-10-04, 10 mM in DMSO;5-chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine
CAS:1356962-34-9
MF:C29H34ClN7O
MW:532.08
EINECS:
Product Categories:
Mol File:1356962-34-9.mol
HG-14-10-04 Structure
HG-14-10-04 Chemical Properties
Boiling point 761.1±70.0 °C(Predicted)
density 1.297±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 13.3 mg/mL (25.00 mM; Need ultrasonic and warming)
form Powder
pka14.62±0.30(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
HG-14-10-04 Usage And Synthesis
UsesHG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer[1][2].
DefinitionChEBI: 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine is a member of piperidines.
IC 50EGFRLR/TM: 15.6 nM (IC50); EGFR19del/TM/CS: 22.6 nM (IC50); EGFRLR/TM/CS: 124.5 nM (IC50); ALK: 20 nM (IC50)
References[1] U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
[2] Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. DOI:10.1021/acs.jmedchem.2c00168
HG-14-10-04 Preparation Products And Raw materials
Tag:HG-14-10-04(1356962-34-9) Related Product Information
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