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ZLN-024

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Company Name: MedChemexpress LLC  
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Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
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ZLN-024 manufacturers

  • ZLN024
  • ZLN024 pictures
  • $89.00
  • 2026-07-27
  • CAS:723249-01-2
  • Purity: 99.82%
  • Supply Ability: 10g
  • ZLN024
  • ZLN024 pictures
  • $89.00
  • 2026-07-27
  • CAS:723249-01-2
  • Purity: 99.82%
  • Supply Ability: 10g
ZLN-024 Basic information
Product Name:ZLN-024
Synonyms:2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine;ZLN-024;2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine;Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-;Inhibitor,AMPK,AMP-activated protein kinase,inhibit,ZLN024,ZLN 024,ZLN-024;ZLN024, 10 mM in DMSO;ZLN-024 (ZLN024);ZLN024
CAS:723249-01-2
MF:C13H13BrN2OS
MW:325.22
EINECS:
Product Categories:
Mol File:723249-01-2.mol
ZLN-024 Structure
ZLN-024 Chemical Properties
Boiling point 443.3±35.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka0.12±0.33(Predicted)
color white to beige
InChI1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3
InChIKeyKWJRSHZSULRJHE-UHFFFAOYSA-N
SMILESS(CCOc2c(cc(cc2)C)Br)c1ncccn1
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 26-39
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
MSDS Information
ZLN-024 Usage And Synthesis
UsesZLN024 is a useful chemical reagent.
Biological ActivityZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172, which is critical for activity, and antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.
in vivo

C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased[1].

IC 50AMPK α2β2γ1: 0.13 μM (EC50); AMPK α1β1γ1: 0.42 μM (EC50); AMPK α2β1γ1: 0.95 μM (EC50)
ZLN-024 Preparation Products And Raw materials
Tag:ZLN-024(723249-01-2) Related Product Information
ZLN-024 hydrochloride 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide AICAR O-304 Metformin hydrochloride MK-0941