- Decapeptide-12
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- $150.00
-
2026-09-15
- CAS:137665-91-9
- Min. Order: 1gram
- Purity: 0.99
- Supply Ability: 5kgs
- Decapeptide-12
-
- $150.00
-
2026-09-15
- CAS:137665-91-9
- Min. Order: 1gram
- Purity: 0.99
- Supply Ability: 5kgs
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| | Decapeptide-12 Basic information |
| Product Name: | Decapeptide-12 | | Synonyms: | Decapeptide-12;Decapeptide-12/ Lumixyl;Decapeptide-12 lumixyl / cosmetic peptide;L-Tyrosine, L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl-;Decapeptide-12 USP/EP/BP;H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH | | CAS: | 137665-91-9 | | MF: | C65H90N18O17 | | MW: | 1395.52 | | EINECS: | 000-000-0 | | Product Categories: | | | Mol File: | 137665-91-9.mol |  |
| | Decapeptide-12 Chemical Properties |
| density | 1.51±0.1 g/cm3(Predicted) | | pka | 3.07±0.10(Predicted) | | Sequence | H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH | | Cosmetics Ingredients Functions | SKIN CONDITIONING
BLEACHING | | InChIKey | OYVFAMLECFSFEI-XJHNTGDTSA-N |
| | Decapeptide-12 Usage And Synthesis |
| Description | Decapeptide-12 is an oligopeptide that is made up of just 10 amino acids. This oligopeptide is known for its anti-tyrosinase activity. Tyrosinase is accountable for producing melanin in the skin. Decapeptide 12 connects to tyrosinase and prevents it from catalyzing the oxidation of phenols – the initial step in melanin creation. It’s able to interfere with tyrosinase and lighten skin. | | Uses | Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3]. | | References | [1] Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. DOI:10.1038/jid.2009.124
[2] Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. DOI:10.1016/j.jbiosc.2015.10.010
[3] Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39. |
| | Decapeptide-12 Preparation Products And Raw materials |
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