- HT-2157
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- $51.00
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2026-07-15
- CAS:303149-14-6
- Purity: 99.43%
- Supply Ability: 10g
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| | HT-2157 Basic information |
| Product Name: | HT-2157 | | Synonyms: | HT-2157;SNAP 37889;1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE;SNAP 37889, CID1471834;HT-2157(SNAP37889);1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one;2H-Indol-2-one, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-;SNAP-37889 (HT-2157) | | CAS: | 303149-14-6 | | MF: | C21H13F3N2O | | MW: | 366.34 | | EINECS: | | | Product Categories: | | | Mol File: | 303149-14-6.mol |  |
| | HT-2157 Chemical Properties |
| Melting point | 141-144 °C | | Boiling point | 484.0±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);81.89(Max Conc. mM)
DMSO:44.0(Max Conc. mg/mL);120.11(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);19.11(Max Conc. mM) | | form | A solid | | pka | -0.36±0.20(Predicted) | | color | Yellow to orange |
| | HT-2157 Usage And Synthesis |
| Uses | SNAP 37889 is a galanin-3 receptor antagonist that suppresses alcohol drinking and morphine self-administration. | | in vivo | The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol[2]. |
| | HT-2157 Preparation Products And Raw materials |
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