- N3-PEG1-CH2COOtBu
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2026-07-24
- CAS:1820717-35-8
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Azido-PEG1-CH2CO2tBu Basic information |
| Product Name: | Azido-PEG1-CH2CO2tBu | | Synonyms: | Azido-PEG1-CH2CO2tBu;Azido-PEG1-CH2CO2-t-butyl ester;tert-Butyl 2-(2-azidoethoxy)acetate;Azido-PEG1-t-butyl acetate;CAS_1820717-35-8;Azido-PEG1-C1-Boc;Azido-PEG1-CH2CO2-t-Bu,Azido-PEG1-CH2CO2-t-butyl Ester;Azido-PEG1-CH2COOtBu | | CAS: | 1820717-35-8 | | MF: | C8H15N3O3 | | MW: | 201.23 | | EINECS: | | | Product Categories: | | | Mol File: | 1820717-35-8.mol |  |
| | Azido-PEG1-CH2CO2tBu Chemical Properties |
| storage temp. | Store at Room Tem. | | solubility | Soluble in DCM, DMF |
| | Azido-PEG1-CH2CO2tBu Usage And Synthesis |
| Description | Azido-PEG1-CH2CO2-t-Bu is a azide (N3) containing PEG linker.The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG1-CH2CO2tBu Preparation Products And Raw materials |
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