Azido-PEG4-t-butyl acetate manufacturers
- N3-PEG4-CH2COOtBu
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2026-02-05
- CAS:864681-04-9
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Azido-PEG4-t-butyl acetate Basic information |
| Product Name: | Azido-PEG4-t-butyl acetate | | Synonyms: | TERT-BUTYL 14-AZIDO-3,6,9,12-TETRAOXATETRADECANOATE;CAS_864681-04-9;Azido-PEG4-t-butyl acetate;Azido-PEG4-CH2-Boc;Azido-PEG4-CH2COOtBu;Azido-PEG4-CH2COOH t-Bu Ester;N3-PEG4-CH2COOtBu/3,6,9,12-Tetraoxatetradecanoic acid, 14-azido-, 1,1-dimethylethyl ester;tert-Butyl 14-Azido-3,6,9,12-tetraoxatetradecan-1-oate | | CAS: | 864681-04-9 | | MF: | C14H27N3O6 | | MW: | 333.38068 | | EINECS: | | | Product Categories: | | | Mol File: | 864681-04-9.mol |  |
| | Azido-PEG4-t-butyl acetate Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Azido-PEG4-t-butyl acetate Usage And Synthesis |
| Description | Azido-PEG4-CH2CO2-t-butyl ester is a PEG reagent containing an azide group and a t-butyl protected carboxyl group. The azide group enables Click Chemistry. The protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. t-butyl ester can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether; Cleavable Linker | | References | [1] Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1.
[2] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228 |
| | Azido-PEG4-t-butyl acetate Preparation Products And Raw materials |
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