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| | PEG6-(CH2CO2H)2 Basic information |
| Product Name: | PEG6-(CH2CO2H)2 | | Synonyms: | PEG6-(CH2CO2H)2;HOOCCH2O-PEG5-CH2COOH;3,6,9,12,15,18-Hexaoxaeicosanedioic acid;CAS_77855-76-6;COOH-CH2-PEG5-CH2-COOH;3,6,9,12,15,18-hexaoxaicosanedioic acid;3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid;PEG6 (CH2CO2H)2,PROTAC Linkers,PEG-6-(CH2CO2H)2,PEG6-(CH2CO2H)2,PEG6(CH2CO2H)2,inhibit,Inhibitor | | CAS: | 77855-76-6 | | MF: | C14H26O10 | | MW: | 354.35 | | EINECS: | | | Product Categories: | PROTAC LINKER | | Mol File: | 77855-76-6.mol |  |
| | PEG6-(CH2CO2H)2 Chemical Properties |
| Boiling point | 524.8±45.0 °C(Predicted) | | density | 1.234±0.06 g/cm3(Predicted) | | storage temp. | Store at Room Tem. | | solubility | Soluble in Water | | pka | 3.09±0.10(Predicted) | | form | Oil | | color | Light yellow to yellow |
| | PEG6-(CH2CO2H)2 Usage And Synthesis |
| Description | PEG6-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1]. | | IC 50 | PEGs | | References | [1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1 |
| | PEG6-(CH2CO2H)2 Preparation Products And Raw materials |
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