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Product Name:VU0071063
CAS:333415-38-6
Purity:98% Package:1G;10G;100G Remarks:VU0071063 is a potent and selective Kir6.2/SUR1 potassium channel activator. It inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells.
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Pharmacodia (Beijing) Co.,Ltd
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| Products Intro: |
Product Name:VU0071063
CAS:333415-38-6
Package:10Mg-100g
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7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE manufacturers
- VU0071063
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- $29.00
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2026-07-15
- CAS:333415-38-6
- Purity: 99.99%
- Supply Ability: 10g
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| | 7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Basic information |
| Product Name: | 7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE | | Synonyms: | 7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE;TOSLAB 808036;7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;VU0071063;1H-Purine-2,6-dione, 7-[[4-(1,1-dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-;7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;Hyperpolarization,KcsA,Potassium Channel,Alzheimer,inhibit,B-cell,Specific,Potent,VU0071063,Insulin,Inhibitor;VU0071063, 10 mM in DMSO | | CAS: | 333415-38-6 | | MF: | C18H22N4O2 | | MW: | 326.39 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | color | white to beige | | InChI | 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3 | | InChIKey | ZFZAIHKQJBMYLO-UHFFFAOYSA-N | | SMILES | CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Usage And Synthesis |
| Description | VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 (EC50 = 7 μM using whole cell patch clamp electrophysiology). It is selective for SUR1-containing Kir6.1 or Kir6.2 channels over SUR2A, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells. | | Uses | VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC50=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships[1][2]. | | in vivo | VU0071063 (50 mg/kg; i.p.; 4 hours) leads to a significant increase in blood glucose at 60 minutes[1]. | Animal Model: | Male C57BL/6 mice (10-12 weeks age)[1] | | Dosage: | 50 mg/kg (Pharmacokinetic analysis) | | Administration: | I.p. | | Result: | Led to a significant increase in blood glucose at 60 minutes. |
| | storage | Store at -20°C | | References | [1] Kharade SV, et al. Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063. J Pharmacol Exp Ther. 2019;370(3):350-359. DOI:10.1124/jpet.119.257204
[2] Raphemot R, et al. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharmacol. 2014;85(6):858-865. DOI:10.1124/mol.114.091884 |
| | 7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Preparation Products And Raw materials |
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