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Bis-aminooxy-PEG1 manufacturers
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| | Bis-aminooxy-PEG1 Basic information |
| Product Name: | Bis-aminooxy-PEG1 | | Synonyms: | Bis-aminooxy-PEG1;Hydroxylamine, O,O'-(oxydi-2,1-ethanediyl)bis-;O-(2-[2-(Aminooxy)ethoxy]ethyl)hydroxylamine;O,O'-(oxybis(ethane-2,1-diyl))bis(hydroxylamine) | | CAS: | 93460-33-4 | | MF: | C4H12N2O3 | | MW: | 136.15 | | EINECS: | | | Product Categories: | | | Mol File: | 93460-33-4.mol |  |
| | Bis-aminooxy-PEG1 Chemical Properties |
| storage temp. | -20°C, protect from light | | solubility | Soluble in Water, DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Bis-aminooxy-PEG1 Usage And Synthesis |
| Description | Bis-aminooxy-PEG1 is a PEG linker containing two aminooxy groups. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy groups can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | | Uses | Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bis-aminooxy-PEG1 Preparation Products And Raw materials |
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