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| | Aminooxy-PEG2-alcohol Basic information |
| | Aminooxy-PEG2-alcohol Chemical Properties |
| Boiling point | 265.9±20.0 °C(Predicted) | | density | 1.116±0.06 g/cm3(Predicted) | | pka | 14.39±0.10(Predicted) |
| | Aminooxy-PEG2-alcohol Usage And Synthesis |
| Description | Aminooxy-PEG2-alcohol is a short PEG linker containing an aminooxy group and a a hydroxyl group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | | Uses | Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. | | IC 50 | PEGs; Non-cleavable Linker | | References | [1] Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c |
| | Aminooxy-PEG2-alcohol Preparation Products And Raw materials |
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