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| | (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) Basic information |
| Product Name: | (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) | | Synonyms: | H-PHE-SER-LEU-LEU-ARG-TYR-NH2;FSLLRY-NH2;(PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN);PHE-SER-LEU-LEU-ARG-TYR- NH2;FSLLRYaMide, (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) aMide (Mouse), (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) aMide (huMan), (Phe1,Ser2,Tyr6)-ThroMbin Receptor (1-6) aMide (huMan);L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinaMide;FSLLRY-NH2 trifluoroacetate salt;FSLLRY-amide | | CAS: | 245329-02-6 | | MF: | C39H60N10O8 | | MW: | 796.96 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) Chemical Properties |
| storage temp. | -20°C | | solubility | Acetonitrile: 0.5 mg/ml; DMSO: 20 mg/ml | | form | powder | | color | white to off-white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | Phe-Ser-Leu-Leu-Arg-Tyr-NH2 | | InChIKey | KMSCNWHRNILNRJ-JNRWAQIZSA-N | | SMILES | N([C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N)C(=O)[C@@H](N)Cc1ccccc1 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) Usage And Synthesis |
| Uses | L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide, is a peptide agonist of proteinase-activated receptor1,and 2 (PAR-1 and -2), and thus can be used to study PAR1,2 action in cells and in animals. | | Biological Activity | FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assays, the peptide inhibits agonist-induced cardiocyte remodeling, and production of cytokines by endothelial cells.', 'The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests th at PAR2 is involved in the maintenance of VH. | | storage | -20°C |
| | (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) Preparation Products And Raw materials |
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