H-SER-LEU-ILE-GLY-ARG-LEU-OH manufacturers
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| | H-SER-LEU-ILE-GLY-ARG-LEU-OH Basic information |
| Product Name: | H-SER-LEU-ILE-GLY-ARG-LEU-OH | | Synonyms: | H-SER-LEU-ILE-GLY-ARG-LEU-OH;PROTEINASE ACTIVATED RECEPTOR 2 AGONIST PEPTIDE (SLIGRL), MOUSE;SER-LEU-ILE-GLY-ARG-LEU;SLIGRL;PAR-2 AGONIST PEPTIDE (SLIGRL), MOUSE;Coagulation Factor II Receptor-Like 1 (1-6) (Mouse, rat), Proteinase Activated Receptor 2 (1-6) (Mouse, rat), SLIGRL, ThroMbin Receptor-Like 1 (1-6) (Mouse, rat);PAR-2 (1-6) (MOUSE, RAT);(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid | | CAS: | 164081-25-8 | | MF: | C29H55N9O8 | | MW: | 657.8 | | EINECS: | | | Product Categories: | | | Mol File: | 164081-25-8.mol |  |
| | H-SER-LEU-ILE-GLY-ARG-LEU-OH Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | pka | 3.38±0.10(Predicted) |
| | H-SER-LEU-ILE-GLY-ARG-LEU-OH Usage And Synthesis |
| Description | PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6) induces relaxation in precontracted rat arteries in a concentration-dependent manner, an effect that can be reduced by the nitric oxide synthase inhibitor L-NNA (Item No. 80220).1 It inhibits keratinocyte growth in the presence and absence of growth factors.2 PAR2 (1-6) inhibits LPS-induced pulmonary neutrophil influx and increases in matrix metalloproteinase-2 (MMP-2) activity in mice.3WARNING This product is not for human or veterinary use. |
| | H-SER-LEU-ILE-GLY-ARG-LEU-OH Preparation Products And Raw materials |
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