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H-Gly-Tyr-Pro-Gly-Gln-Val-OH

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H-Gly-Tyr-Pro-Gly-Gln-Val-OH manufacturers

  • PAR 4 (1-6)
  • PAR 4 (1-6) pictures
  • $572.00
  • 2026-07-27
  • CAS:225779-44-2
  • Purity:
  • Supply Ability: 10g
H-Gly-Tyr-Pro-Gly-Gln-Val-OH Basic information
Product Name:H-Gly-Tyr-Pro-Gly-Gln-Val-OH
Synonyms:GLY-TYR-PRO-GLY-GLN-VAL;PROTEINASE ACTIVATED RECEPTOR 4 AGONIST PEPTIDE (GYPGQV), HUMAN;PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN;PAR-4 (1-6) (HUMAN);PAR 4 (1-6);GYPGQV, Coagulation Factor II Receptor-Like 3 (1-6) (huMan), Proteinase Activated Receptor 4 (1-6) (huMan), ThroMbin Receptor-Like 3 (1-6) (huMan);Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt;Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt
CAS:225779-44-2
MF:C28H41N7O9
MW:619.67
EINECS:
Product Categories:
Mol File:225779-44-2.mol
H-Gly-Tyr-Pro-Gly-Gln-Val-OH Structure
H-Gly-Tyr-Pro-Gly-Gln-Val-OH Chemical Properties
storage temp. -15°C
solubility H2O: >2mg/mL
form powder
color white to tan
SequenceGly-Tyr-Pro-Gly-Gln-Val
Safety Information
WGK Germany 3
MSDS Information
H-Gly-Tyr-Pro-Gly-Gln-Val-OH Usage And Synthesis
DescriptionPAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence. It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 μM. PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.
UsesPAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR4). PAR 4 (1-6) TFA acts as a PAR4-specific agonist[1].
References[1] H Andersen, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11189-93. DOI:10.1073/pnas.96.20.11189
[2] E Bretschneider, et al. Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol. 2001 Apr;132(7):1441-6. DOI:10.1038/sj.bjp.0703947
H-Gly-Tyr-Pro-Gly-Gln-Val-OH Preparation Products And Raw materials
Tag:H-Gly-Tyr-Pro-Gly-Gln-Val-OH(225779-44-2) Related Product Information
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2 H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) Vkgils-NH2 Coagulation factor II receptor-like 2 (1-6) amide (human) Coagulation factor II receptor-like 2 (1-6) amide (mouse) PAR-4 (1-6) amide (human) H-Ser-Leu-Ile-Gly-Arg-Leu-OH H2N-aypgqv-OH H-Gly-Tyr-Pro-Gly-Gln-Val-OH