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| | tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate Basic information |
| | tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate Chemical Properties |
| Melting point | 38-42 °C | | Boiling point | 114°C 0,1mm | | density | 1.092±0.06 g/cm3(Predicted) | | Fp | 110 °C | | storage temp. | 2-8°C | | pka | 14.96±0.10(Predicted) | | form | Solid | | color | White to pale brown | | InChI | InChI=1S/C11H22N2O3/c1-11(2,3)16-10(15)13-6-4-12(5-7-13)8-9-14/h14H,4-9H2,1-3H3 | | InChIKey | VRXIOAYUQIITBU-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCN(CCO)CC1 | | CAS DataBase Reference | 77279-24-4(CAS DataBase Reference) |
| Hazard Codes | C,N,T | | Risk Statements | 36/37/38-50-25 | | Safety Statements | 26-36/37/39-61-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 2933599590 | | Storage Class | 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Aquatic Acute 1 |
| | tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate Usage And Synthesis |
| Uses | Boc-Piperazine-OH is a PROTAC Linker in SJ46420 (HY-168635)[1]. | | Synthesis | General procedure: synthesis of tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (57): 1-(2-hydroxyethyl)piperazine (3.0 g, 23.0 mmol) was dissolved in dry tetrahydrofuran (THF) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.5 g, 25.3 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated to half of the initial volume by rotary evaporator. The concentrated mixture was poured into deionized water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to afford the light yellow oily product tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (5.3 g, quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.46 (s, 9H), 2.44-2.46 (m, 4H), 2.54-2.57 (m, 2H), 2.66 (m, J = 5.3 Hz, 1H), 3.42-3.45 (m, 4H), 3.62 (q, J = 5.3 Hz, 2H). | | References | [1] Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. DOI:10.1038/s41467-024-52966-3 |
| | tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate Preparation Products And Raw materials |
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