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| | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH acetate salt Basic information |
| | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH acetate salt Chemical Properties |
| density | 1.522±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 3.327±0.20(predicted) | | color | White to off-white | | Water Solubility | Soluble in water (1 mg/ml). | | Sequence | Arg-Pro-Pro-Gly-Phe-Ser-Pro | | InChIKey | CRROPKNGCGVIOG-UHFFFAOYSA-N | | SMILES | NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH acetate salt Usage And Synthesis |
| Uses | Bradykinin Fragment 1-7 is used in research on the specificity and kinetics of kininase(s). Bradykinin dilates blood vessels via the release of prostacyclin, nitric oxide, and Endothelium Derived Hyperpolarizing Factor. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids. | | Definition | ChEBI: [des-Phe(8), des-Arg(9)]-bradykinin is a seven-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, and Pro residues joined in sequence by peptide bonds. It is a metabolite of bradykinin lacking the Phe residue at position 8 and the Arg residue at position 9. It has a role as a human metabolite and a rat metabolite. It is a conjugate base of a [des-Phe(8), des-Arg(9)]-bradykinin(1+). | | Biological Activity | Bradykinin (BK) is a pro-inflammatory mediator and a neuromediator. It modulates several vascular and renal functions. Bradykinin (BK) plays a key role in inducing vascular permeability and mitogenesis. It helps to activate the liberation of nitric oxide in inflammatory and cancer tissues. |
| | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH acetate salt Preparation Products And Raw materials |
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