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| | 1,1,1,3,5,5,5-Heptamethyltrisiloxane Basic information | | Uses |
| Product Name: | 1,1,1,3,5,5,5-Heptamethyltrisiloxane | | Synonyms: | 3H-Heptamethyltrisiloxane;1,1,1,3,5,5,5-HEPTAMETHYLTRISILOXANE;DOW CORNING 1107 WATER REPELLENT AND POWDER TREATMENT;1,1,1,3,5,5,5-HEPTAMETHYLTRISILOXANE, 97 %;40M25);40M40,commercialgrade;1,1,1,3,5,5,5-Heptamethyltrisiloxane(Bis(trimethylsiloxy)methylsilane);Bis-(trimethylsilyloxy)-methylsilane | | CAS: | 1873-88-7 | | MF: | C7H22O2Si3 | | MW: | 222.5 | | EINECS: | 217-496-1 | | Product Categories: | Industrial/Fine Chemicals;Si (Classes of Silicon Compounds);Siloxanes;Si-O Compounds;Organometallic Reagents;Organosilicon | | Mol File: | 1873-88-7.mol |  |
| | 1,1,1,3,5,5,5-Heptamethyltrisiloxane Chemical Properties |
| Melting point | <0°C | | Boiling point | 142 °C (lit.) | | density | 0.819 g/mL at 25 °C (lit.) | | vapor pressure | 8.5hPa at 25℃ | | refractive index | n20/D 1.382(lit.) | | Fp | 82 °F | | storage temp. | 15-25°C | | solubility | Chloroform (Soluble), Methanol (Slightly) | | form | clear liquid | | color | Colorless to Almost colorless | | Specific Gravity | 0.8136 | | Water Solubility | Miscible with acetone, ethanol, diethyl ether. Insoluble in water. | | Hydrolytic Sensitivity | 3: reacts with aqueous base | | BRN | 1748455 | | Henry's Law Constant | 1.1×10-7 mol/(m3Pa) at 25℃, Ebert et al. (2023) | | Stability: | Stable. Flammable. Incompatible with strong oxidizing agents. | | InChI | 1S/C7H22O2Si3/c1-10(8-11(2,3)4)9-12(5,6)7/h10H,1-7H3 | | InChIKey | QNWOFLWXQGHSRH-UHFFFAOYSA-N | | SMILES | C[SiH](O[Si](C)(C)C)O[Si](C)(C)C | | LogP | 6.2 at 20℃ | | CAS DataBase Reference | 1873-88-7(CAS DataBase Reference) | | NIST Chemistry Reference | Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-,(1873-88-7) | | EPA Substance Registry System | Trisiloxane, 1,1,1,3,5,5,5-heptamethyl- (1873-88-7) |
| Hazard Codes | Xi | | Risk Statements | 10-36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 1993 3/PG 2 | | WGK Germany | 3 | | F | 10-21 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29319090 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3 |
| | 1,1,1,3,5,5,5-Heptamethyltrisiloxane Usage And Synthesis |
| Uses | Heptamethyltrisiloxane is used to catalyze reduction reactions in organic syntheses. | | Description | Bis (trimethylsiloxy) methylsilane acts as an important raw material
and intermediate used in organic synthesis, pharmaceutical and
dyestuff. For example, it can be used for the platinum-catalyzed
aromatic C-H silylation of arenes. It can also be used for the
silylation of aryl iodides. | | Chemical Properties | colourless liquid | | Uses | 1,1,1,3,5,5,5-Heptamethyltrisiloxane is a Basic material for synthetic polyalkyleneoxide modified heptamethyltrisiloxane which is a kind of specific structure surfactant for pesticide additives, coating additives, etc. | | Uses | Bis(trimethylsiloxy)methylsilane is an important raw material and intermediate used in organic synthesis, pharmaceutical and dyestuff. | | Uses | 1,1,1,3,5,5,5-Heptamethyltrisiloxane can be used for the aromatic C-H silylation of arenes in the presence of a platinum complex catalyst.
It can also be used as a reagent to synthesize:
- 3-Octyl-1,1,1,3,5,5,5-heptamethyltrisiloxane, an agricultural adjuvant and sensory performance enhancer used in cosmetic formulations.
- Isoindigo-based conjugated polymer with siloxane-terminated solubilizing group.
- Monosiloxy esters with a variety of acids.
| | Flammability and Explosibility | Flammable | | Synthesis | A solution of dichloromethylsilane (20 g, 0.174 mol) in hexane (60 mL) was slowly added dropwise at -30 °C to a mixed solution containing trimethylsilanol (40 g, 0.45 mol) and pyridine (33.2 g, 0.42 mol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was sequentially washed with water and dried over sodium sulfate. The final product was purified by atmospheric pressure distillation in 34% yield. | | Toxics Screening Level | The ITSL for heptamethyltrisiloxane has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time. | | References | https://www.alfa.com/zh-cn/catalog/H60586/
Murata, Miki, et al. "Silylation of Aryl Iodides with 1,1,1,3,5,5,5 -Heptamethyltrisiloxane Catalyzed by Transition-Metal Complexes." Synlett 2007.09(2007):1387-1390.
Murata, Miki, et al. "Platinum-Catalyzed Aromatic C—H Silylation of Arenes with 1,1,1,3,5,5,5-Heptamethyltrisiloxane." Cheminform38.50 (2007):no-no. |
| | 1,1,1,3,5,5,5-Heptamethyltrisiloxane Preparation Products And Raw materials |
| Raw materials | Pentasiloxane, 1,1,1,3,5,7,9,9,9-nonamethyl--->2,4,6,8-Tetramethylcyclotetrasiloxane-->PENTAMETHYLCYCLOPENTASILOXANE-->Octamethyltrisiloxane-->1,3-BIS(TRIMETHYLSILOXY)-1,3-DIMETHYLDISILOXANE-->SODIUM TRIMETHYLSILANOLATE-->hydroxytrimethylsilane-->Dichloromethylsilane-->METHYLSILANE-->Hexasiloxane, 1,1,1,3,5,7,9,11,11,11-decamethyl--->Chlorotrimethylsilane | | Preparation Products | Ethanol, 2-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propoxy]- |
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