|
|
| | 4-(CHLOROMETHYL)BENZYL ALCOHOL 99 Basic information |
| | 4-(CHLOROMETHYL)BENZYL ALCOHOL 99 Chemical Properties |
| Melting point | 58-60 °C (lit.) | | Boiling point | 276℃ | | density | 1.195 | | Fp | 123℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | wooly solid | | pka | 14.27±0.10(Predicted) | | color | White | | InChI | InChI=1S/C8H9ClO/c9-5-7-1-3-8(6-10)4-2-7/h1-4,10H,5-6H2 | | InChIKey | OGALXJIOJZXBBP-UHFFFAOYSA-N | | SMILES | C1(CO)=CC=C(CCl)C=C1 |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 1759 8/PG 2 | | WGK Germany | 3 | | HS Code | 2906290090 |
| | 4-(CHLOROMETHYL)BENZYL ALCOHOL 99 Usage And Synthesis |
| Uses | 4-(Chloromethyl)benzyl alcohol may be used in the synthesis of 4-(chloromethyl)benzyl acetate. | | General Description | 4-(Chloromethyl)benzyl alcohol can be synthesized from 4-(chloromethyl)benzoyl chloride. | | Synthesis | Example 1: (1) Synthesis of [4-(chloromethyl)benzyl]alcohol: To a solution of tetrahydrofuran containing 4-(chloromethyl)benzoic acid (60 mL THF), 1M borane-THF solution (90 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, methanol (50 mL) was added to quench the reaction. Subsequently, the solvent was removed by rotary evaporator and the obtained residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 4/1 to 3/1) to afford 4-(chloromethyl)benzyl alcohol (8.84 g, 96% yield) as a colorless solid. | | References | [1] Patent: WO2003/106403, 2003, A1. Location in patent: Page 23
[2] Patent: US5387709, 1995, A
[3] Patent: WO2015/51045, 2015, A2. Location in patent: Page/Page column 161-162
[4] Patent: US2016/215288, 2016, A1. Location in patent: Paragraph 0602; 0611
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4481 - 4486 |
| | 4-(CHLOROMETHYL)BENZYL ALCOHOL 99 Preparation Products And Raw materials |
|