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2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-

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Products Intro: Product Name:3-(4-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS:790652-68-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:3-(4-(AMINOMETHYL)-1-OXO-ISOINDOLIN 2-YL)PIPERIDINE-2,6-DIONE
CAS:790652-68-5
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
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Products Intro: Product Name:3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
CAS:790652-68-5
Purity:95%+ Remarks:MC739123
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Products Intro: Product Name:3-(4-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS:790652-68-5
Purity:95%+ Package:5g;10g;1kg;10kg
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Products Intro: Product Name:3-[4-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione
CAS:790652-68-5
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Basic information
Product Name:2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
Synonyms:2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;3-[4-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione;Lenalidomide-4-aminomethyl;3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;3-[4-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione;3-[4-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione?, Lenalidomide-4-aminomethyl;3-[4-(Aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
CAS:790652-68-5
MF:C14H15N3O3
MW:273.29
EINECS:
Product Categories:E3 ligase Ligan
Mol File:790652-68-5.mol
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Structure
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Chemical Properties
Boiling point 594.9±50.0 °C(Predicted)
density 1.400±0.06 g/cm3(Predicted)
pka10.72±0.40(Predicted)
Safety Information
MSDS Information
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Usage And Synthesis
UsesLenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].
IC 50Cereblon
References[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Preparation Products And Raw materials
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