| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
- H-L-CYS(TRT)-NH2 HCL
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- $1.00
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2019-09-02
- CAS:166737-85-5
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 200kg
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| | H-L-Cys(Trt)-NH2 HCl Basic information |
| Product Name: | H-L-Cys(Trt)-NH2 HCl | | Synonyms: | S-TRITYL-L-CYSTEINE AMIDE HYDROCHLORIDE;H-Cys(Trt)-NH2;(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanamide;S-Trityl-L-cysteinaMide, 98%;PropanaMide,2-aMino-3-[(triphenylMethyl)thio]-, (2R)-;H-L-Cys(Trt)-NH2;L-Cys(Trt)-NH2;S-Trityl-L-cysteine amide≥ 98% (HPLC) | | CAS: | 166737-85-5 | | MF: | C22H22N2OS | | MW: | 362.49 | | EINECS: | | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 166737-85-5.mol |  |
| | H-L-Cys(Trt)-NH2 HCl Chemical Properties |
| Boiling point | 543.2±50.0 °C(Predicted) | | density | 1.203±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 15.83±0.50(Predicted) | | form | Powder | | color | Off-white |
| | H-L-Cys(Trt)-NH2 HCl Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | (2R)-2-Amino-3-[(triphenylmethyl)thio]propanamide is a useful building block for organic synthesis. | | Synthesis | General procedure for the synthesis of S-trityl-L-cysteamine from (9H-fluoren-9-yl)methyl (R)-(1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate: (R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate (4 g. 6.84 mmol) was dissolved in N,N-dimethylformamide (20 mL), piperidine (0.14 mL, 1.368 mmol) was added and the reaction was carried out for 4 h at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was washed with saturated aqueous sodium chloride solution and subsequently extracted with dichloromethane. The organic phase was dried with anhydrous sodium sulfate, concentrated and purified by column chromatography (eluent: methanol/dichloromethane, 1%-5% gradient) to afford the title product S-trityl-L-cysteamine as a yellow oil (2.3 g, yield: 92%). | | References | [1] Patent: CN106432014, 2017, A. Location in patent: Paragraph 0079; 0083; 0084; 0085; 0119; 0123; 0124; 0125
[2] Patent: WO2008/116302, 2008, A1. Location in patent: Page/Page column 43-44 |
| | H-L-Cys(Trt)-NH2 HCl Preparation Products And Raw materials |
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