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| | Moxonidine hydrochloride Basic information |
| Product Name: | Moxonidine hydrochloride | | Synonyms: | MOXONIDINE HYDROCHLORIDE;MOXONIDINE HCL;BDF-5895 HCL;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-3H-pyrimidin-2-amine hydrochloride;6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride | | CAS: | 75438-58-3 | | MF: | C9H13Cl2N5O | | MW: | 278.14 | | EINECS: | | | Product Categories: | Imidazoline binding site;Antihypertensive | | Mol File: | 75438-58-3.mol |  |
| | Moxonidine hydrochloride Chemical Properties |
| Melting point | 189° | | InChI | InChI=1S/C9H14ClN5O.ClH/c1-9(15-8-11-3-4-12-8)13-6(10)5-7(14-9)16-2;/h5,13H,3-4H2,1-2H3,(H2,11,12,15);1H | | InChIKey | SKWXZGXGBKLLOD-UHFFFAOYSA-N | | SMILES | C1(C)(NC2NCCN=2)N=C(OC)C=C(Cl)N1.[H]Cl | | CAS DataBase Reference | 75438-58-3(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | UV6260290 |
| | Moxonidine hydrochloride Usage And Synthesis |
| Description | Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component. | | Uses | Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM. | | Application | Moxonidine hydrochloride has been used:
as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method.
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC).
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN). | | Biological Activity | Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component. |
| | Moxonidine hydrochloride Preparation Products And Raw materials |
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