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Imidazolidine

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Imidazolidine Basic information
Product Name:Imidazolidine
Synonyms:1,3-Diazacyclopentane;Imidazolidine;mizuolin;Imidazolidine ISO 9001:2015 REACH;Imidazolidine (6CI, 8CI, 9CI, ACI);Imidazolidine,90% in water;imidazoline;Oil soluble imidazoline
CAS:504-74-5
MF:C3H8N2
MW:72.11
EINECS:263-058-8
Product Categories:
Mol File:504-74-5.mol
Imidazolidine Structure
Imidazolidine Chemical Properties
Melting point 68.2-68.8 °C
Boiling point 92.8±8.0 °C(Predicted)
density 0.892±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka10.33±0.20(Predicted)
InChIInChI=1S/C3H8N2/c1-2-5-3-4-1/h4-5H,1-3H2
InChIKeyWRYCSMQKUKOKBP-UHFFFAOYSA-N
SMILESC1NCCN1
EPA Substance Registry SystemImidazolidine (504-74-5)
Safety Information
MSDS Information
Imidazolidine Usage And Synthesis
UsesThe imidazolines, was discovered at American Cyanamid in the early 1980s. Extensive research has led to the development of four commercial compounds: imazapyr, imazamethabenzmethyl, imazethapyr, and imazaquin. Like the sulfonylureas, the imidazolines are extremely active at low rates.
DefinitionChEBI: Imidazolidine is a saturated organic heteromonocyclic parent, a member of imidazolidines and an azacycloalkane.
SynthesisImidazolidine is produced by a cyclocondensation reaction between ethylenediamine and an aldehyde. The yield is 70 %. The reaction conditions are that one of the amino groups of ethylenediamine is present using the secondary amine form.
Imidazolidine synthesis
Synthesis of Imidazolidine derivatives including:
(1) Synthesis of 1,3-dibenzyl-2-arylimidazolidine
It is divided into three steps: the first step is the condensation of ethylenediamine with aldehyde in dry benzene to obtain N,N′-dibenzylidene-1,2-diamine, and the second step is the reduction of N,N′-dibenzylidene ethylenediamine to N,N′-dibenzylidene ethylenediamine in ethanol with sodium borohydride. The substituted diamine was condensed with an aryl aldehyde in the final step to give 1,3-dibenzyl-2-arylimidazolidine.
Synthesis of 1,3-dibenzyl-2-arylimidazolidine
(2)Synthesis of 2-iminoimidazolidine
Method: Ethylenediamine reacts with cyanobromide to form 2-iminoimidazolidine by substitution-cyclisation.
Synthesis of 2-iminoimidazolidine
(3) Synthesis of Imidazolidin-2-one
Methods: Imidazolidin-2-one was prepared by heating ethylenediamine and urea with 75% yield.
Synthesis of Imidazolidin-2-one
Structure and conformationDihydroimidazole is a five-membered, nonplanar, and nonaromatic heterocycle, derived by the partial reduction of one of the two double bonds of the imidazole ring. The dihydroimidazoles are also referred to as imidazolines and there are three possible regioisomeric forms: 4,5-dihydroimidazole (2-imidazoline), 2,5-dihydroimidazole (3-imidazoline), and 2,3- dihydroimidazole (4-imidazoline). The 2- and 3-imidazolines contain an imine center, while 4-imidazoline contains an alkene substructure. Among these three isomeric forms, the chemistry of 2-imidazoline is more developed than 3- and 4-imidazolines.
3- and 4-imidazolines
References[1] Patent: WO2008/83038, 2008, A1. Location in patent: Page/Page column 25
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987, p. 1695 - 1700
[3] Synthesis, 1998, # 10, p. 1463 - 1466
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