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| | 4-Methyl-3-nitropyridine Basic information |
| | 4-Methyl-3-nitropyridine Chemical Properties |
| Melting point | 24-28 °C | | Boiling point | 238 °C | | density | 1.228 g/mL at 25 °C | | refractive index | n20/D 1.549 | | Fp | 227 °F | | storage temp. | Inert atmosphere,Room Temperature | | pka | 1.87±0.18(Predicted) | | form | powder to lump to clear liquid | | color | White or Colorless to Yellow | | BRN | 118796 | | InChI | InChI=1S/C6H6N2O2/c1-5-2-3-7-4-6(5)8(9)10/h2-4H,1H3 | | InChIKey | JLNRJMGYBKMDGI-UHFFFAOYSA-N | | SMILES | C1=NC=CC(C)=C1[N+]([O-])=O | | CAS DataBase Reference | 5832-44-0(CAS DataBase Reference) |
| Hazard Codes | Xn,T,Xi | | Risk Statements | 22-37/38-41-36/37/38 | | Safety Statements | 26-39-36 | | RIDADR | 2810 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
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| | 4-Methyl-3-nitropyridine Usage And Synthesis |
| Chemical Properties | Deliquescent cryst | | Uses | 4-Methyl-3-nitropyridine may be used as a starting material in the synthesis of ethyl 6-azaindole-2-carboxylate and also 3-substituted azaindoles. | | Uses | 4-METHYL-3-NITROPYRIDINE is a useful research chemical. | | General Description | 4-Methyl-3-nitropyridine, a substituted nitropyridine, can be prepared by the malonation of 4-methoxy-3-nitropyridine with sodium diethyl malonate. | | Synthesis | The general procedure for synthesizing 3-nitro-4-methylpyridine from 4-methylpyridine is as follows:1) In step 1) of Example 1, prepare a reaction solution by adding 60 g of nitrogen pentoxide solid to 300 g of liquid sulfur dioxide at -30° C. and stirring sufficiently until completely dissolved.2) Dissolve 30 g of 4-methylpyridine in 120 g of liquid sulfur dioxide and maintain the temperature at -30° C.3 ) Slowly drop the reaction solution into 300 g of ice water for 5 minutes. ) Slowly add the nitrogen pentoxide-sulfur dioxide solution prepared in step 1) dropwise to the 4-methylpyridine solution, and react for 5 min. 4) Slowly pour the reaction solution into 300 g of ice water, and hydrolyze thoroughly. 5) Adjust the pH of the hydrolyzed solution to 8-9 using sodium carbonate. 6) Add 290 g of toluene for two extractions, and combine the extracts. 7) Remove the solvent by vacuum distillation to obtain 39 g of 3- Nitro-4-methylpyridine. The purity of the product was 99.0% by gas chromatography. | | References | [1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 3, p. 538 - 541
[2] Acta Chemica Scandinavica, 1994, vol. 48, # 12, p. 1001 - 1006
[3] Acta Chemica Scandinavica, 1994, vol. 48, # 2, p. 181 - 182
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995, # 6, p. 1211 - 1216
[5] Acta Chemica Scandinavica, 1996, vol. 50, # 6, p. 556 - 557 |
| | 4-Methyl-3-nitropyridine Preparation Products And Raw materials |
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