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| | 2,4-Dichloro-5-methylpyridine Basic information |
| Product Name: | 2,4-Dichloro-5-methylpyridine | | Synonyms: | 2,4-DICHLORO-5-METHYLPYRIDINE;2,4-dichloro-5-methylpyridine
2,4-dichloro-5-picoline;4,6-Dichloro-3-picoline;2,4-Dichloro-5-methylpyridine Synonyms: 2,4-DICHLORO-5-METHYLPYRIDINE;2,4-Dichloro-5-methylpyridine 98%;Pyridine, 2,4-dichloro-5-methyl-;2,4-Dichloro-5-methylpyridine ISO 9001：2015 REACH;2,4-Dichloro-5-methylpyridine (or) 2,4-Dichloro-5-picoline | | CAS: | 56961-78-5 | | MF: | C6H5Cl2N | | MW: | 162.02 | | EINECS: | | | Product Categories: | Heterocycle-Pyridine series;Pyridine | | Mol File: | 56961-78-5.mol |  |
| | 2,4-Dichloro-5-methylpyridine Chemical Properties |
| Boiling point | 221.2±35.0 °C(Predicted) | | density | 1.319±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 0.38±0.10(Predicted) | | form | Liquid | | color | Colorless | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C6H5Cl2N/c1-4-3-9-6(8)2-5(4)7/h2-3H,1H3 | | InChIKey | DUPJNQNLAKJWKU-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=C(C)C(Cl)=C1 |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2933399990 |
| | 2,4-Dichloro-5-methylpyridine Usage And Synthesis |
| Chemical Properties | colorless liquid | | Uses | 2,4-Dichloro-5-methylpyridine is used as pharmaceutical intermediates. | | Synthesis | A solution of phosphorus oxychloride in dichloromethane was added to a mixture of 2-chloro-5-methylpyridine 1-oxide and triethylamine in dichloromethane at 0 ℃. After stirring for 2 hours, the mixture is reacted at room temperature for 24 hours. After that, the water was added and the mixture was neutralized with a sodium hydroxide solution. The organic layer was washed with a saturated brine solution and the aqueous layer was extracted with ethyl acetate and washed with a saturated brine solution. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 2,4-Dichloro-5-methylpyridine. The by-product of this reaction is 2,6-dichloro-3-methyl-pyridine.
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| | 2,4-Dichloro-5-methylpyridine Preparation Products And Raw materials |
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