3-CHLORO-N-METHYLBENZYLAMINE manufacturers
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| | 3-CHLORO-N-METHYLBENZYLAMINE Basic information |
| | 3-CHLORO-N-METHYLBENZYLAMINE Chemical Properties |
| Boiling point | 97 °C/0.6 mmHg (lit.) | | density | 1.072 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.5395(lit.) | | Fp | 115 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 9.34±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid | | Sensitive | Air Sensitive | | InChI | 1S/C8H10ClN/c1-10-6-7-3-2-4-8(9)5-7/h2-5,10H,6H2,1H3 | | InChIKey | ZPNLAQVYPIAHTO-UHFFFAOYSA-N | | SMILES | CNCc1cccc(Cl)c1 | | NIST Chemistry Reference | N-methyl-m-chlorobenzylamine(39191-07-6) | | EPA Substance Registry System | Benzenemethanamine, 3-chloro-N-methyl- (39191-07-6) |
| Hazard Codes | Xn | | Risk Statements | 10-22-38-41 | | Safety Statements | 16-26-36/37/39 | | RIDADR | UN 1993 3/PG 1 | | WGK Germany | 2 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | Ⅲ | | HS Code | 29214990 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2 |
| | 3-CHLORO-N-METHYLBENZYLAMINE Usage And Synthesis |
| Synthesis | GENERAL STEPS: An ethanol solution of methylamine (33% w/v, 17 mL) was slowly added dropwise to 4-chlorobenzyl chloride (2.0 g, 12.42 mmol), followed by heating the reaction mixture to reflux overnight. Upon completion of the reaction, ethanol was removed by distillation under reduced pressure by rotary evaporator. The residue was diluted with deionized water (100 mL) and washed with ethyl acetate (150 mL × 2). The aqueous phase was adjusted to pH 8 with solid potassium carbonate and then extracted with ethyl acetate (100 mL × 2). All organic phases were combined, washed with deionized water (100 mL), dried over anhydrous sodium sulfate, and finally the target product, N-methyl-3-chlorobenzylamine (1.7 g), was obtained by concentration under reduced pressure. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 2.22 (s, 3H), 3.32 (br s, 1H), 3.62 (s, 2H), 7.25-7.38 (m, 4H); ESI-MS (m/z) 156 (M + H). | | References | [1] Patent: WO2017/199103, 2017, A1. Location in patent: Page/Page column 28 |
| | 3-CHLORO-N-METHYLBENZYLAMINE Preparation Products And Raw materials |
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