- 5-Ethoxyindole
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2025-04-04
- CAS:10501-17-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1tone
- 5-Ethoxyindole
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- $1.00
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2020-01-05
- CAS:10501-17-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1kg-1000kg
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| | 5-Ethoxyindole Basic information |
| | 5-Ethoxyindole Chemical Properties |
| Melting point | 35-36 °C | | Boiling point | 192 °C(Press: 11 Torr) | | density | 1.132±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | pka | 16.75±0.30(Predicted) | | Appearance | Light brown to brown Solid | | CAS DataBase Reference | 10501-17-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | HS Code | 2933998090 |
| | 5-Ethoxyindole Usage And Synthesis |
| Synthesis | E1. Synthesis of 5-ethoxyindole: Commercially available 5-hydroxyindole (18 g, 13.5 mmol), anhydrous K2CO3 (93.5 g, 5 eq.), and ethyl iodide (40.5 mL, 3.75 eq.) were dissolved in acetone (180 mL) and the reaction was stirred at 50 °C under argon protection. The progress of the reaction was monitored by thin layer chromatography (TLC, spreading agent dichloromethane:methanol=95:5) until the 5-hydroxyindole completely disappeared (about 4 days). After completion of the reaction, the mixture was filtered, the solids were washed with acetone, the filtrates were combined and concentrated to give 17.67 g (90% yield) of the target product 5-ethoxyindole, which was pure enough to be used directly in the subsequent reaction. Melting point: 144-146°C (ethanol recrystallization). | | References | [1] Patent: WO2007/96395, 2007, A1. Location in patent: Page/Page column 123
[2] Patent: WO2009/24190, 2009, A1. Location in patent: Page/Page column 81
[3] Patent: WO2009/24613, 2009, A1. Location in patent: Page/Page column 78
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 12, p. 2865 - 2874 |
| | 5-Ethoxyindole Preparation Products And Raw materials |
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