atrasentan manufacturers
- atrasentan
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2026-06-30
- CAS:173937-91-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- atrasentan
-
-
2020-01-10
- CAS:173937-91-2
- Min. Order: 1KG
- Purity: 98%; 99%
- Supply Ability: 500g;1kg； 25kg
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| | atrasentan Basic information |
| Product Name: | atrasentan | | Synonyms: | atrasentan;(+)-A 127722;A-147627;(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid;(2S,3S,4R)-4-(1,3-BENZODIOXOL-5-YL)-1-[2-(DIBUTYLAMINO)-2-OXOETHYL]-2-(4-METHOXYPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID;A127722, CID 5310990;Atrasentan (ABT-627);(+)-A 127722; ABT-627; A 127722; ABT 627 | | CAS: | 173937-91-2 | | MF: | C29H38N2O6 | | MW: | 510.62 | | EINECS: | | | Product Categories: | API | | Mol File: | 173937-91-2.mol |  |
| | atrasentan Chemical Properties |
| Melting point | 122-124° | | Boiling point | 659.4±55.0 °C(Predicted) | | density | 1.188±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.49±0.60(Predicted) | | color | Off-White | | InChIKey | MOTJMGVDPWRKOC-QPVYNBJUSA-N | | SMILES | N1(CC(N(CCCC)CCCC)=O)C[C@H](C2=CC=C3OCOC3=C2)[C@@H](C(O)=O)[C@@H]1C1=CC=C(OC)C=C1 |
| | atrasentan Usage And Synthesis |
| Uses | Palliative treatment of bone pain due to
metastatic prostate cancer and disease progression (endothelin
(ETA) receptor antagonist). | | Uses | Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation. | | Definition | ChEBI: Atrasentan is a member of pyrrolidines. | | in vivo | Atrasentan (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats[1]. Aatrasentan (ABT-627, 10 mg/kg, i.p.) as well as Taxotere alone inhibited the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model[2]. |
| | atrasentan Preparation Products And Raw materials |
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