| Company Name: |
Lynnchem |
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Company Name: |
Novachemistry |
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
nargenicin A1 manufacturers
- Nargenicin
-
- $1840.00
-
2026-04-20
- CAS:70695-02-2
- Purity:
- Supply Ability: 10g
|
| | nargenicin A1 Basic information |
| Product Name: | nargenicin A1 | | Synonyms: | Antibiotic CP-47444;CP-47444;Nodusmicin 9-(1H-pyrrole-2-carboxylate);Antibiotic 47444;NSC 355066;1H-Pyrrole-2-carboxylic acid, (1E,3R,4S,7S,8aS,10aR,11R,12R,13R,14R,14aS,14bS)-3,4,6,7,8,8a,10a,11,12,13,14,14a-dodecahydro-14-hydroxy-4-[(1R)-1-hydroxyethyl]-7-methoxy-1,3,13-trimethyl-6-oxo-11,14b-epoxy-14bH-naphth[2,1-e]oxecin-12-yl ester;Nargenicin A1
DISCONTINUED;Nargenicin A1, Antibiotic agent | | CAS: | 70695-02-2 | | MF: | C28H37NO8 | | MW: | 515.599 | | EINECS: | | | Product Categories: | | | Mol File: | 70695-02-2.mol |  |
| | nargenicin A1 Chemical Properties |
| Boiling point | 718.3±60.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C,protect from light | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | Off-white powder. | | pka | 14.03±0.20(Predicted) | | color | Off-white |
| | nargenicin A1 Usage And Synthesis |
| Description | Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS. Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells. In vivo, nargenicin (50 mg/kg, p.o.) reduces the number of colony-forming units (CFUs) in infected kidneys by 100,000-fold in a murine model of S. aureus infection. | | Uses | Nargenicin A1 is an antibiotic with a broad efficacy. | | storage | +4°C | | References | [1] JAE KYUNG SOHNG. Production, isolation and biological activity of nargenicin from Nocardia sp. CS682[J]. Archives of Pharmacal Research, 2008, 31 10: 1339-1345. DOI: 10.1007/s12272-001-2115-0
[2] RONALD E PAINTER. Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.[J]. Chemistry & biology, 2015, 22 10: 1362-1373. DOI: 10.1016/j.chembiol.2015.08.015
[3] JIN CHEOL YOO. Nargenicin attenuates lipopolysaccharide-induced inflammatory responses in BV-2 cells.[J]. Neuroreport, 2009, 20 11: 1007-1012. DOI: 10.1097/wnr.0b013e32832d2239
[4] SEUNG HYUN KIM Tae S K Jin Cheol Yoo. Nargenicin enhances 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced leukemia cell differentiation via PKCβI/MAPK pathways[J]. Biochemical pharmacology, 2009, 77 11: Pages 1694-1701. DOI: 10.1016/j.bcp.2009.03.004 |
| | nargenicin A1 Preparation Products And Raw materials |
|