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| | 2-Cyano-5-fluorobenzaldehyde Basic information |
| Product Name: | 2-Cyano-5-fluorobenzaldehyde | | Synonyms: | 2-Cyano-5-fluorobenzaldehyde;Benzonitrile, 4-fluoro-2-formyl-;2-Cyano-5-fluorobenzaldehyde ISO 9001：2015 REACH;4-Fluoro-2-forMylbenzonitrile | | CAS: | 894779-76-1 | | MF: | C8H4FNO | | MW: | 149.12 | | EINECS: | | | Product Categories: | | | Mol File: | 894779-76-1.mol |  |
| | 2-Cyano-5-fluorobenzaldehyde Chemical Properties |
| Boiling point | 288.0±25.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | Light yellow to light brown Solid |
| | 2-Cyano-5-fluorobenzaldehyde Usage And Synthesis |
| Synthesis | To an anhydrous tetrahydrofuran (THF, 20 mL) solution of 2-bromo-4-fluorobenzonitrile (5.0 g, 25.0 mmol) was slowly added isopropylmagnesium chloride (PrMgCl, 2.0 M solution of THF, 15.0 mL, 30.0 mmol) at -30 °C. The reaction temperature was maintained at -30°C with continuous stirring for 3 hours. Subsequently, N,N-dimethylformamide (DMF, 5.80 mL, 75.0 mmol) was added to the reaction system. The reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the mixture was cooled to -10 °C, 2 M hydrochloric acid (37 mL) was slowly added and stirred at this temperature for 20 min. The reaction solution was concentrated in vacuum to 1/3 of the original volume and then extracted with ethyl acetate (EtOAc, 3 times). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give the target product 4-fluoro-2-formylbenzonitrile (3.9 g, 71% yield). | | References | [1] Patent: WO2011/68821, 2011, A1. Location in patent: Page/Page column 137 |
| | 2-Cyano-5-fluorobenzaldehyde Preparation Products And Raw materials |
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