5-Bromo-2-fluoropyridine-3-carboxaldehyde

5-Bromo-2-fluoropyridine-3-carboxaldehyde Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:	4006356688 18621169109
Email:	market03@meryer.com

Company Name:	ShangHai DEMO Chemical Co.,Ltd
Tel:	400-021-7337 2355568890
Email:	sales@demochem.com

5-Bromo-2-fluoropyridine-3-carboxaldehyde manufacturers

5-Bromo-2-fluoropyridine-3-carboxaldehyde Basic information

Product Name:	5-Bromo-2-fluoropyridine-3-carboxaldehyde
Synonyms:	5-Bromo-2-fluoro-pyridin-3-carbaldehyde;5-Bromo-2-fluoro-3-pyridinecarboxaldehyde;5-Bromo-2-fluoropyridine-3-carboxaldehyde;5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine;3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-;5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH;5-bromo-2-fluoronicotinaldehyde;5-Bromo-2-fluoro-3-formylpyridine
CAS:	875781-15-0
MF:	C6H3BrFNO
MW:	204
EINECS:
Product Categories:	Building Blocks;Pyridine;Fluorine series
Mol File:	875781-15-0.mol

5-Bromo-2-fluoropyridine-3-carboxaldehyde Chemical Properties

Boiling point	258.2±35.0 °C(Predicted)
density	1.778±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-4.59±0.20(Predicted)
form	Powder
color	Off-white to pale yellow
InChI	InChI=1S/C6H3BrFNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H
InChIKey	MUYVOGAJRCBWCY-UHFFFAOYSA-N
SMILES	C1(F)=NC=C(Br)C=C1C=O

Safety Information

Safety Statements	24/25
HS Code	29333990

MSDS Information

5-Bromo-2-fluoropyridine-3-carboxaldehyde Usage And Synthesis

Uses	5-Bromo-2-fluoro-3-pyridinecarboxaldehyde is used in the synthesis of [2,3-d]pyrimidine derivatives useful as Raf kinase inhibitors. Also used in the preparation of XIa inhibitors.
Synthesis	2591-86-8 766-11-0 875781-15-0 The general procedure for the synthesis of 5-bromo-2-fluoro-3-formylpyridine using N-formylpiperidine and 2-fluoro-5-bromopyridine as starting materials was as follows: the intermediate 5-bromo-1H-pyrazolo[3,4-b]pyridine was first prepared; subsequently, the crude product was ground in hexane (replacing the operation of crystallization from cyclohexane) according to the method described in WO2006015124 to obtain the target compound 5-bromo-2-fluoro-3-formylpyridine, the product was an off-white solid in 68% yield. Mass spectrometry (electrospray positive ion mode) showed m/z of 203.8 and 205.7 [M+H]+.
References	[1] Patent: US2008/293706, 2008, A1. Location in patent: Page/Page column 27; 85 [2] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 73-74

5-Bromo-2-fluoropyridine-3-carboxaldehyde Preparation Products And Raw materials

Raw materials	5-Bromo-2-fluoropyridine-->N-Formylpiperidine-->Ethyl formate-->Lithium diisopropylamide-->Tetrahydrofuran
Preparation Products	5-Bromo-1H-pyrazo[3,4-b]pyridine-->Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate-->1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid-->5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine-->2-Propanesulfinamide, N-[1-(5-bromo-2-fluoro-3-pyridinyl)ethylidene]-2-methyl-, [N(Z),S(R)]-

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