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| | 5-Bromo-2-fluoropyridine-3-carboxaldehyde Basic information |
| Product Name: | 5-Bromo-2-fluoropyridine-3-carboxaldehyde | | Synonyms: | 5-Bromo-2-fluoro-pyridin-3-carbaldehyde;5-bromo-2-fluoronicotinaldehyde;5-Bromo-2-fluoro-3-pyridinecarboxaldehyde;5-Bromo-2-fluoro-3-formylpyridine;5-Bromo-2-fluoropyridine-3-carboxaldehyde;5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine;3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-;5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH | | CAS: | 875781-15-0 | | MF: | C6H3BrFNO | | MW: | 204 | | EINECS: | | | Product Categories: | Building Blocks;Pyridine;Fluorine series | | Mol File: | 875781-15-0.mol |  |
| | 5-Bromo-2-fluoropyridine-3-carboxaldehyde Chemical Properties |
| Boiling point | 258.2±35.0 °C(Predicted) | | density | 1.778±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -4.59±0.20(Predicted) | | form | Powder | | color | Off-white to pale yellow | | InChI | InChI=1S/C6H3BrFNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H | | InChIKey | MUYVOGAJRCBWCY-UHFFFAOYSA-N | | SMILES | C1(F)=NC=C(Br)C=C1C=O |
| Safety Statements | 24/25 | | HS Code | 29333990 |
| | 5-Bromo-2-fluoropyridine-3-carboxaldehyde Usage And Synthesis |
| Uses | 5-Bromo-2-fluoro-3-pyridinecarboxaldehyde is used in the synthesis of [2,3-d]pyrimidine derivatives useful as Raf kinase inhibitors. Also used in the preparation of XIa inhibitors. | | Synthesis | The general procedure for the synthesis of 5-bromo-2-fluoro-3-formylpyridine using N-formylpiperidine and 2-fluoro-5-bromopyridine as starting materials was as follows: the intermediate 5-bromo-1H-pyrazolo[3,4-b]pyridine was first prepared; subsequently, the crude product was ground in hexane (replacing the operation of crystallization from cyclohexane) according to the method described in WO2006015124 to obtain the target compound 5-bromo-2-fluoro-3-formylpyridine, the product was an off-white solid in 68% yield. Mass spectrometry (electrospray positive ion mode) showed m/z of 203.8 and 205.7 [M+H]+. | | References | [1] Patent: US2008/293706, 2008, A1. Location in patent: Page/Page column 27; 85
[2] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 73-74 |
| | 5-Bromo-2-fluoropyridine-3-carboxaldehyde Preparation Products And Raw materials |
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