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| | 5-Bromo-3-pyridinecarboxaldehyde Basic information |
| | 5-Bromo-3-pyridinecarboxaldehyde Chemical Properties |
| Melting point | 98-102 °C | | Boiling point | 251.1±20.0 °C(Predicted) | | density | 1.683±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 1.07±0.20(Predicted) | | form | Crystalline Powder | | color | White to off-white | | Sensitive | Air Sensitive | | InChI | InChI=1S/C6H4BrNO/c7-6-1-5(4-9)2-8-3-6/h1-4H | | InChIKey | NGUVGKAEOFPLDT-UHFFFAOYSA-N | | SMILES | C1=NC=C(Br)C=C1C=O | | CAS DataBase Reference | 113118-81-3(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-36/38-43 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1 |
| | 5-Bromo-3-pyridinecarboxaldehyde Usage And Synthesis |
| Uses | 5-Bromonicotinaldehyde (5-Bromo-3-pyridinecarboxaldehyde) can replace anilines (anilines) compounds and is used in the synthesis of naphthyridines and diazobenzenes[1]. | | Synthesis | 5-Bromo-3-pyridinecarboxaldehyde can be used as a pharmaceutical and chemical synthesis intermediate. In the existing technology, its synthesis method is to use 3,5-dibromo pyridine as raw material and exchange it with butyllithium bromide under ultra-low temperature (-78°C) conditions to prepare 5-Bromo-3-pyridinecarboxaldehyde. Or use 3,5-dibromopyridine as raw material and combine butyllithium and n-butylmagnesium chloride at -15°C to synthesize the product. | | References | [1] European Journal of Medicinal Chemistry, 2006, vol. 41, # 7, p. 847 - 861
[2] Tetrahedron Letters, 2001, vol. 42, # 29, p. 4841 - 4844
[3] Patent: CN107628990, 2018, A. Location in patent: Paragraph 0020; 0021; 0038; 0039; 0040; 0041; 0042-0046
[4] Patent: US2013/65905, 2013, A1. Location in patent: Paragraph 0189
[5] Patent: WO2004/814, 2003, A1. Location in patent: Page 77 |
| | 5-Bromo-3-pyridinecarboxaldehyde Preparation Products And Raw materials |
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