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| | ethyl 3-amino-3-phenylpropanoate Basic information |
| Product Name: | ethyl 3-amino-3-phenylpropanoate | | Synonyms: | ethyl 3-amino-3-phenylpropanoate;Benzenepropanoic acid, b-aMino-, ethyl ester;3-Amino-3-phenylpropanoic acid ethyl ester hydrochloride;3-Amino-3-phenylpropanoic acid ethyl ester;Ethyl 3-amino-3-phenylpropionate;Ethyl 3-amino-3-phenyl-propanoate hydrochloride;beta-Aminobenzenepropanoic acid ethyl ester;NSC 38811 | | CAS: | 6335-76-8 | | MF: | C11H15NO2 | | MW: | 193.24 | | EINECS: | | | Product Categories: | | | Mol File: | 6335-76-8.mol |  |
| | ethyl 3-amino-3-phenylpropanoate Chemical Properties |
| Melting point | 111-112℃ (water ethanol ) | | Boiling point | 155 °C(Press: 13 Torr) | | density | 1.075±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 7.75±0.10(Predicted) |
| Risk Statements | 22 | | HS Code | 2922390090 |
| | ethyl 3-amino-3-phenylpropanoate Usage And Synthesis |
| Synthesis | To a 500 mL three-necked flask was added 50 mL of ethanol, 9.3 g of malonic acid and 18.2 g of ammonium acetate, heated to 50°C, and 10.0 g of benzaldehyde was slowly added dropwise. After the dropwise addition, the reaction was heated to reflux. After the reaction was completed, the mixture was cooled to below 10°C and 40 g of thionyl chloride was slowly added dropwise. The mixture was heated to reflux for 16 hours, followed by distillation to remove ethanol. To the residue 50 mL of dichloromethane was added and the pH was adjusted to 6-7 with 5 N NaOH solution. the organic layer was separated and the aqueous layer was extracted with dichloromethane. The organic layers were combined and concentrated to give 14.2 g of colorless oily material, which was analyzed by HPLC for 98% purity and 78% yield. | | References | [1] Patent: CN106083624, 2016, A. Location in patent: Paragraph 0019 |
| | ethyl 3-amino-3-phenylpropanoate Preparation Products And Raw materials |
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