- 2-Chloro-3-pyridinamine
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- $1.10 / 1g
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2025-11-18
- CAS:6298-19-7
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 2-Chlorpyridin-3-amin
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- $6.00 / 1KG
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2025-09-25
- CAS:6298-19-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 2-Chloro-3-pyridinamine Basic information |
| | 2-Chloro-3-pyridinamine Chemical Properties |
| Melting point | 76-78 °C (lit.) | | Boiling point | 130-134 °C (12.7517 mmHg) | | density | 130 | | refractive index | 1.5110 (estimate) | | Fp | 185 °C | | storage temp. | 2-8°C | | solubility | 30g/l | | pka | 2.42±0.10(Predicted) | | form | Crystalline Powder, Crystals, and/or Chunks | | color | Off-white to yellow to pink | | PH | 7 (30g/l, H2O, 20℃) | | Water Solubility | Soluble in methanol and water. (30 g/L). | | BRN | 109814 | | InChI | 1S/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2 | | InChIKey | MEQBJJUWDCYIAB-UHFFFAOYSA-N | | SMILES | Nc1cccnc1Cl | | CAS DataBase Reference | 6298-19-7(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Amino-2-chloropyridine(6298-19-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN2811 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids |
| | 2-Chloro-3-pyridinamine Usage And Synthesis |
| Chemical Properties | off-white to yellow to pink crystalline powder, | | Uses | It is an intermediate of medicine and agricultural chemicals. It is involved in the Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds. | | Synthesis | Dissolve 188g (2mol) of 3-aminopyridine in 10% hydrochloric acid: 900g (10%, 2.46mol), completely dissolved and mixed, the volume ratio of the solution to dichloromethane: 400g, sodium hypochlorite solution: 800g (10%, 1.07mol) as a preset unit time volume ratio, and then according to the unit time volume ratio at room temperature (the specific temperature range of 10 -30 the same below) will be pumped into the first stage extraction centrifuge for extraction centrifugation; after that, separate the organic phase and the organic phase continuously. Then, according to the unit time volume ratio at room temperature (the specific temperature range of room temperature is 10 -30 the same below) will be three separate and at the same time continuously pumped into the first stage of the extraction centrifuge extraction centrifugation; after that, the separation of organic phase and aqueous phase, and retain the organic phase, the aqueous phase, industrial hydrochloric acid: 59g (content of 31%, 0.5mol), dichloromethane: 200g, and sodium hypochlorite solution: 400g (10%, 0.54mol) four of the volume ratio, the content of the organic phase: 500g (content of 10 percent, 1.07mol), the volume ratio of the organic phase: 800g (content of 10 percent, 1.07mol) (content 10%, 0.54 mol) as a preset unit time volume ratio, and then in accordance with the unit time volume ratio at room temperature, the four were separately and simultaneously pumped continuously into the second stage of the extraction centrifuge extraction centrifuge; after that, the separation of organic and aqueous phases, and retaining the organic phase, and put the aqueous phase into the next stage of the extraction centrifuge; the subsequent amount of hydrochloric acid, methylene chloride, and sodium hypochlorite solution used in each stage of extraction centrifuge volume The amount of hydrochloric acid, dichloromethane and sodium hypochlorite solution used in each subsequent stage of extraction centrifuge was reduced by half, a total of five stages of continuous extraction reaction (each stage of extraction centrifugal reaction time was 3h), after which the organic phase was combined as 3-amino-2-chloropyridine solution; a total of 962g of solution was obtained, which was analyzed by liquid chromatography with external standard method, and the content of the external standard method was calculated to be 24.4%, the weight of the 3-amino-2-chloropyridine was calculated to be 234.5g, and the molar yield of 3-amino-2-chloropyridine was 91.3 The molar yield of 3-amino-2-chloropyridine was 91.3% (as 3-aminopyridine), purity was 98.4%. |
| | 2-Chloro-3-pyridinamine Preparation Products And Raw materials |
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