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| | 4-Methoxyphenylhydrazine hydrochloride Basic information |
| | 4-Methoxyphenylhydrazine hydrochloride Chemical Properties |
| Melting point | 160-162 °C (dec.)(lit.) | | storage temp. | Keep Cold | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Powder, Crystals and/or Chunks | | color | Slightly pink to gray to purple | | Water Solubility | soluble | | BRN | 3566583 | | Stability: | Light Sensitive | | InChI | InChI=1S/C7H10N2O.ClH/c1-10-7-4-2-6(9-8)3-5-7;/h2-5,9H,8H2,1H3;1H | | InChIKey | FQHCPFMTXFJZJS-UHFFFAOYSA-N | | SMILES | C1(NN)=CC=C(OC)C=C1.Cl | | CAS DataBase Reference | 19501-58-7(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 36/37-36-26 | | RIDADR | 2811 | | WGK Germany | 3 | | Hazard Note | Irritant/Harmful | | HazardClass | IRRITANT, KEEP COLD | | PackingGroup | III | | HS Code | 29280090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Skin Sens. 1 |
| | 4-Methoxyphenylhydrazine hydrochloride Usage And Synthesis |
| Description |
4-Methoxyphenylhydrazine hydrochloride is a kind of midbody that is mainly used for producing phenylhydrazine, and can also be used to make other Chemicals. The reparation technology of 4-Methoxyphenylhydrazine hydrochloride comprises aniline diazonium and benzene diazonium chloride diazo benzene chloride two-step process.
| | Chemical Properties | slightly pink to greyish-purple powder | | Uses | 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. | | Synthesis | 4-Methoxyphenylhydrazine hydrochloride Preparation Process: Take hydrochloric acid and sodium nitrite and add them sequentially to aniline, where the molar ratio of aniline to hydrochloric acid to sodium nitrite is 1:2.3 to 3.2:1 to 1.1, and sodium nitrite is added at 0 to 5°C. The reaction temperature is 0 to 22°C, and the reaction time is 30 to 90 minutes. Then add ammonium sulfite and hydrochloric acid according to a molar ratio to aniline of 1:2 to 3.5:2.5 to 3.0. After reduction, hydrolysis, and acidification, the product can be obtained by filtration or centrifugation. | | References | [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3322 - 3336
[2] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 1, p. 1 - 11
[3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] Journal of Organic Chemistry, 2011, vol. 76, # 13, p. 5295 - 5308 |
| | 4-Methoxyphenylhydrazine hydrochloride Preparation Products And Raw materials |
| Raw materials | p-Anisidine-->Hydrochloric acid-->Sodium nitrite-->Stannous chloride | | Preparation Products | 1-(4-METHOXYPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE-->2,3,4,9-tetrahydro-6-methoxy-1H-pyrido[3,4-b]indol-1-one-->5-METHOXY-2-METHYLINDOLE-->2,3,3-Trimethyl-5-methoxy-3H-indole-->6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE-->Tepoxalin-->Acemetacin-->2H-Imidazole-2-thione, 1,3-dihydro-1-[(4-methoxyphenyl)amino]-4-methyl-5-phenyl--->ETHYL 1-(4-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->(5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER |
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